Abstract
Thrombogenicity is one of the most important biocompatibility markers of artificial material. Anticoagulation is commonly used to reduce thrombogenicity of the extracorporeal circuit (ECC) during intermittent hemodialysis (IHD). In some situations, systemic anticoagulants are contraindicated. The aim of our study was to compare thrombogenicity parameters during IHD with three different methods without a systemic anticoagulation effect. In a prospective, randomized, and crossover study, we examined 10 stable patients during IHD with (i) regular saline flushes of ECC; (ii) regional citrate anticoagulation (RCA); and (iii) AN69 ST membrane after ECC priming according to the manufacturer's recommendations. Before IHD and after 10, 60, 120, and 240 min, we measured the platelet count and the plasma concentrations of platelet factor 4 (PF4) and thrombin/antithrombin complexes (TAT). All 10 procedures with RCA were successfully completed after 4 h, whereas 6/10 procedures with saline flushes and 5/10 procedures with AN69 ST were finished prematurely because of clotting (P < 0.05). The TAT production was significantly increased during saline flushes and AN69 ST compared with RCA (P < 0.05). Platelet activation demonstrated by rising PF...Continue Reading
References
Sep 1, 1987·The American Journal of Medicine·S J SchwabP A Dennis
Jan 1, 1987·Contributions to Nephrology·K AndrassyJ Bommer
Sep 19, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sylvie LavaudJacques Chanard
Oct 18, 2003·Current Opinion in Nephrology and Hypertension·Jonathan Himmelfarb, Raymond M Hakim
Sep 8, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mareille GrittersMenso J Nubé
Sep 15, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jacques ChanardMichel Thomas
Sep 15, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Sylvie LavaudJacques Chanard
Oct 20, 2006·Renal Failure·Patrick T Murray, Marcie J Hursting
May 3, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Pieter EvenepoelYves Vanrenterghem
Jun 29, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pavlina RichtrovaRadek Perlik
Aug 25, 2007·Thrombosis Research·Raghav RajgopalStephen G Shaughnessy
Dec 25, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jacques ChanardPhilippe Rieu
Jan 10, 2009·Artificial Organs·Ansgar ErlenkötterJörg Vienken
Feb 7, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Justyna Kozik-JarominJoachim Böhler
Citations
Mar 8, 2012·Artificial Organs·Paul S Malchesky
Jun 4, 2013·Trials·Patrick RossignolMaurice Laville
May 23, 2014·Medizinische Klinik, Intensivmedizin und Notfallmedizin·R D Frank
Nov 27, 2014·Kidney International·Björn K I MeijersPieter Evenepoel
Jul 10, 2014·Kidney International·Maurice LavillePatrick Rossignol
Sep 15, 2015·Artificial Organs·Manja AntonicRafael Ponikvar
Sep 1, 2016·Hemodialysis International·Malin Skagerlind, Bernd Stegmayr
May 9, 2018·Medizinische Klinik, Intensivmedizin und Notfallmedizin·M SchmitzC Willam
Sep 1, 2017·Critical Care Medicine·Stanislas FaguerOlivier Cointault
Jun 14, 2018·PloS One·Jakob GubensekJens Hartmann
May 11, 2018·Hemodialysis International·Vincent BrunotVincent Pernin
Jan 21, 2018·BMC Nephrology·Eng Kuang LimShimi Isaac
Jul 10, 2012·Intensive Care Medicine·Miet SchetzGreet Van den Berghe
Nov 21, 2013·The International Journal of Artificial Organs·Masa KnehtlJadranka Buturovic-Ponikvar
Nov 21, 2013·The International Journal of Artificial Organs·Filip FranssonBernd Stegmayr
Aug 6, 2019·Hemodialysis International·Thierry KrummelThierry Hannedouche
Dec 21, 2019·BMC Nephrology·Ting LinXinling Liang
Mar 3, 2017·Blood Purification·Vanessa NseirSéverine Beaudreuil
Apr 14, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Björn MeijersPieter Evenepoel
Dec 5, 2017·European Journal of Clinical Pharmacology·Malin S E Skagerlind, Bernd G Stegmayr
Nov 2, 2014·The International Journal of Artificial Organs·Tobias KyrkBernd Stegmayr
Aug 5, 2021·Clinical Kidney Journal·Ines VandenboschBjörn Meijers