Evaluation of three different proton pump inhibitors with amoxicillin and metronidazole in retreatment for Helicobacter pylori infection

Journal of Clinical Gastroenterology
Kazunari MurakamiToshio Fujioka

Abstract

We compared the eradication results of retreatment of eradication with proton pump inhibitor (PPI) plus amoxicillin and metronidazole for patients with Helicobacter pylori infection not eradicated by initial treatment with PPI plus amoxicillin and clarithromycin. In Japan, the guideline proposes that the use of metronidazole in a triple therapy containing PPI, PPI plus amoxicillin and metronidazole is desirable in retreatment. However, there are no reports comparing various retreatment using different PPIs. After initial treatment failure with a PPI plus amoxicillin and clarithromycin, 169 patients were randomized to a PPI (rabeprazole, lansoprazole, or omeprazole) plus amoxicillin and metronidazole given b.i.d. for 7 days. Pretreatment susceptibility testing showed a high level of clarithromycin resistance (78%). The over all eradication rates were similar with the 3 PPIs, 91.1% range 90.1 to 91.4 with intention-to-treat analysis. The presence of metronidazole resistance reduced the eradication rate by approximately 40% (from 96.6% to 57.1%, P<0.05). In Japan, the combination of a PPI plus amoxicillin and metronidazole provide excellent eradication rates after initial treatment failure with a PPI plus amoxicillin and clarithro...Continue Reading

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Citations

Apr 27, 2012·Gastroenterology Research and Practice·Javier P Gisbert
Sep 23, 2008·World Journal of Gastroenterology : WJG·Javier P Gisbert
Mar 5, 2011·Gastroenterología y hepatología·Javier P Gisbert
Mar 23, 2010·Helicobacter·Masahiro AsakaUNKNOWN Japanese Society for Helicobacter Research
Dec 25, 2010·Therapeutic Advances in Gastroenterology·Javier P Gisbert
Apr 10, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhammad Miftahussurur, Yoshio Yamaoka
Mar 31, 2010·Expert Review of Gastroenterology & Hepatology·Seiji ShiotaYoshio Yamaoka
Dec 26, 2012·Expert Review of Gastroenterology & Hepatology·Seiji ShiotaYoshio Yamaoka

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