Abstract
We compared the eradication results of retreatment of eradication with proton pump inhibitor (PPI) plus amoxicillin and metronidazole for patients with Helicobacter pylori infection not eradicated by initial treatment with PPI plus amoxicillin and clarithromycin. In Japan, the guideline proposes that the use of metronidazole in a triple therapy containing PPI, PPI plus amoxicillin and metronidazole is desirable in retreatment. However, there are no reports comparing various retreatment using different PPIs. After initial treatment failure with a PPI plus amoxicillin and clarithromycin, 169 patients were randomized to a PPI (rabeprazole, lansoprazole, or omeprazole) plus amoxicillin and metronidazole given b.i.d. for 7 days. Pretreatment susceptibility testing showed a high level of clarithromycin resistance (78%). The over all eradication rates were similar with the 3 PPIs, 91.1% range 90.1 to 91.4 with intention-to-treat analysis. The presence of metronidazole resistance reduced the eradication rate by approximately 40% (from 96.6% to 57.1%, P<0.05). In Japan, the combination of a PPI plus amoxicillin and metronidazole provide excellent eradication rates after initial treatment failure with a PPI plus amoxicillin and clarithro...Continue Reading
References
Nov 1, 1986·The Journal of Antimicrobial Chemotherapy·S Narikawa
Jan 1, 1998·Gut·P J Kahrilas, G Shi
Sep 11, 1998·The American Journal of Gastroenterology·N VakilD McSorley
Dec 29, 1998·Annals of Internal Medicine·T FurutaE Kaneko
Sep 24, 1999·Alimentary Pharmacology & Therapeutics·T Ishizaki, Y Horai
Jul 18, 2000·Antimicrobial Agents and Chemotherapy·M KatoD H Kwon
Sep 30, 2000·Alimentary Pharmacology & Therapeutics·K AdachiY Kinoshita
Jun 26, 2001·Journal of Gastroenterology and Hepatology·A NagaharaN Sato
Oct 31, 2001·Helicobacter·M AsakaT Shimoyama
Jan 30, 2002·International Journal of Antimicrobial Agents·K MurakamiM Nasu
Oct 23, 2002·Alimentary Pharmacology & Therapeutics·K MurakamiT Arita
Dec 21, 2002·Alimentary Pharmacology & Therapeutics·K MurakamiJ Kagawa
May 14, 2003·Journal of Gastroenterology·Masahiro AsakaUNKNOWN Japan Helicobacter pylori Eradication Study Group
Jul 10, 2003·Alimentary Pharmacology & Therapeutics·H IsomotoS Kohno
Feb 8, 2006·Journal of Gastroenterology and Hepatology·Kazunari MurakamiTsuyoshi Arita
Citations
Mar 23, 2010·Acta Pharmacologica Sinica·Hai-lun ZhengJian-ming Xu
Apr 27, 2012·Gastroenterology Research and Practice·Javier P Gisbert
Jul 29, 2010·Journal of Clinical Biochemistry and Nutrition·Makoto SasakiTakashi Joh
Sep 23, 2008·World Journal of Gastroenterology : WJG·Javier P Gisbert
Mar 5, 2011·Gastroenterología y hepatología·Javier P Gisbert
Aug 8, 2009·British Journal of Clinical Pharmacology·Mario Del TaccaCorrado Blandizzi
Mar 21, 2009·Helicobacter·Nobue UekiChoitsu Sakamoto
May 19, 2011·Helicobacter·Kazutoshi HoriTakayuki Matsumoto
Jun 19, 2013·Helicobacter·Daisuke AsaokaNobuhiro Sakaki
Mar 23, 2010·Helicobacter·Masahiro AsakaUNKNOWN Japanese Society for Helicobacter Research
Mar 30, 2013·Expert Opinion on Pharmacotherapy·Alicia C MarinJavier P Gisbert
Jun 28, 2016·The Journal of Antimicrobial Chemotherapy·Ignasi PuigXavier Calvet
Sep 28, 2016·The American Journal of Gastroenterology·Qi ChenHong Lu
Dec 25, 2010·Therapeutic Advances in Gastroenterology·Javier P Gisbert
Apr 10, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhammad Miftahussurur, Yoshio Yamaoka
Apr 18, 2018·Helicobacter·Neus MuñozXavier Calvet
Apr 17, 2019·Helicobacter·Mireia BaylinaIgnasi Puig
Mar 31, 2010·Expert Review of Gastroenterology & Hepatology·Seiji ShiotaYoshio Yamaoka
Dec 26, 2012·Expert Review of Gastroenterology & Hepatology·Seiji ShiotaYoshio Yamaoka
Nov 27, 2020·Therapeutic Advances in Gastroenterology·Mariko HojoAkihito Nagahara