PMID: 2110392Mar 1, 1990Paper

Evaluation of three midazolam-xylazine mixtures. Preliminary trials in dogs

Veterinary Surgery : VS
W J TranquilliG J Benson

Abstract

The depressant effects of midazolam and xylazine on the central nervous system (CNS) were evaluated in 12 dogs. Xylazine was administered to six dogs (1.1 mg/kg intravenously [IV]) followed in 5 minutes by midazolam (1.0 mg/kg intramuscularly [IM]). In a second group of six dogs, xylazine (2.2 mg/kg IM) was followed in 5 minutes by midazolam (1.0 mg/kg IV). Both drug regimens induced rapid and profound sedation or anesthesia. Duration of action varied with the doses and routes of administration. Dogs given the high dose of xylazine IM had an arousal time of 95.4 +/- 8.9 minutes and a walking time of 155.4 +/- 8.8 minutes. These values exceeded the IV xylazine values threefold. Partial reversal of CNS depression was accomplished with either a benzodiazepine antagonist (flumazenil) or an alpha-2 antagonist (yohimbine). In a separate trial, a mixture of xylazine (0.55 mg/kg), midazolam (1.0 mg/kg), and butorphanol (0.1 mg/kg) with and without glycopyrrolate was evaluated in eight dogs. As with the xylazine-midazolam combinations, the CNS depressant effect of this mixture was clinically indistinguishable from anesthesia achieved with other rapid-acting injectable agents. Clinical signs of CNS depression were readily and completely ...Continue Reading

References

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Citations

Jun 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·J E IlkiwE P Steffey
Feb 1, 2013·American Journal of Veterinary Research·Turi K AarnesJeffrey Lakritz
Mar 1, 1992·The Veterinary Clinics of North America. Small Animal Practice·J E Ilkiw
Mar 1, 1992·The Veterinary Clinics of North America. Small Animal Practice·W J Tranquilli, G J Benson
Mar 1, 1992·The Veterinary Clinics of North America. Small Animal Practice·W J Tranquilli
Jul 1, 1994·Veterinary Surgery : VS·J D JacobsonE P Smith
Mar 29, 2014·Veterinary Ophthalmology·Kyle L TofflemireR David Whitley
Jun 2, 2020·Veterinary Ophthalmology·Andrea L MinellaGillian J McLellan
Sep 6, 2020·Veterinary Ophthalmology·Minna P MustikkaThomas S C Grönthal
Dec 9, 2004·The Journal of Veterinary Medical Science·Minoru OhtaYutaka Mizuno

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