Evaluation of thyroid function during pregnancy: first-trimester reference intervals for thyroid-stimulating hormone and free thyroxine

Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición
Luis García de Guadiana RomualdoJorge Nuevo García

Abstract

The physiological changes that occur during pregnancy affect the physiology of the thyroid gland. Consequently, interpretation of thyroid function markers during pregnancy requires trimester-specific reference intervals. The aims of our study were to: 1) establish first-trimester reference intervals for biochemical markers of thyroid function [thyroid-stimulating hormone (TSH) and free thyroxine (T4)] and 2) to establish the prevalence of autoimmune thyroid disease in pregnant women resident in Cartagena (Murcia, Spain). A total of 441 women between weeks 11 and 13 of pregnancy were included in this study. A blood sample was extracted from all women to measure TSH, free T4 and antithyroid antibodies. Reference intervals for TSH and free T4 were determined in 400 pregnant women without autoimmune thyroid disease or known thyroid disease. Autoimmune thyroid disease was detected in 23 pregnant women (5.2%) who showed TSH levels higher than those in pregnant women without thyroid autoimmunity. First-trimester reference intervals were as follows: TSH: 0.130-3.710 mUI/L; free T4: 0.89-1.50 ng/dL. These reference intervals differed from the non-pregnant reference intervals used in our laboratory. The reference intervals established ar...Continue Reading

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Citations

Jul 31, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Manuel Lombardo GrifolMaría Vega Valdazo Revenga
May 15, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Javier Aller Granda, Antonio Rabal Artal
Oct 27, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Lluís VilaUNKNOWN Grupo de Trabajo de Trastornos por Deficiencia de Yodo y Disfunción Tiroidea de la Sociedad Española de Endocrinología y Nut
Sep 18, 2012·Medicina clínica·Lluís VilaUNKNOWN Sociedad Española de Ginecología y Obstetricia
May 17, 2015·Revista de psiquiatrí́a y salud mental·Julio A GuijaJosé Giner
Dec 1, 2014·Medicina clínica·Juan J DíezSergio Donnay
Oct 17, 2013·European Journal of Endocrinology·Lluís VilaManuel Puig-Domingo
Jul 11, 2013·Journal of Thyroid Research·Ladan MehranFereidoun Azizi

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