Evaluation of thyroid gland as an organ at risk after breast cancer radiotherapy: a systematic review and meta-analysis

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
L DarvishA Amraee

Abstract

Radiotherapy can often lead to thyroid dysfunction. Some studies demonstrated that treatment of breast cancer by RT can expose thyroid gland to high doses of radiation. The aim of this systematic review is to evaluate consideration of thyroid gland as an organ at risk. In this systematic review and meta-analysis to select initial studies, a comprehensive search by two independent reviewers was performed. Electronical databases following: Web of Science, Google Scholar, Scopus, PubMed, Elsevier, Embase, ProQuest and Persian databases such as Iranmedex, Magiran, and SID were searched. All searches were restricted to English language between 1985 and 2017. A random effect meta-analysis is applied to estimate pooled effect size across initial studies. Funnel plot with Egger's test is used to assess potential publication bias. Totally, five studies (478 samples) were included in meta-analysis. The meta-analyses of result showed that thyroid gland is affected by radiotherapy significantly and the TSH increased after radiotherapy (z = 2.68, P = 0.007). The pooled estimate of difference mean for TSH was 0.90 (95% CI 0.24, 1.55). In studies among patients with breast cancer RT, hypothyroidism was reported more than other thyroid disorde...Continue Reading

References

May 1, 1986·Acta Radiologica. Oncology·H Joensuu, J Viikari
Jan 1, 1974·Endocrinology·R M Bassiri, R D Utiger
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·S L HancockL S Constine
May 18, 2004·Cancer Treatment Reviews·Barbara A Jereczek-FossaRoberto Orecchia
Sep 24, 2004·International Journal of Radiation Oncology, Biology, Physics·Roger TellRolf Lewensohn
Mar 12, 2005·CA: a Cancer Journal for Clinicians·M Kara BucciMack Roach
May 19, 2005·Clinical Breast Cancer·Mariantonietta ColozzaMartine J Piccart
Jun 1, 2005·American Journal of Clinical Oncology·Allie Garcia-SerraWilliam M Mendenhall
Dec 17, 2005·Thyroid : Official Journal of the American Thyroid Association·Johannes L P KuijpensJan-Willem W Coebergh
Oct 19, 2007·PLoS Medicine·Jan P VandenbrouckeUNKNOWN STROBE Initiative
Jan 24, 2008·Cancer·Grace L SmithThomas A Buchholz
Mar 17, 2009·International Journal of Radiation Oncology, Biology, Physics·Kristin Valborg ReinertsenSophie D Fosså
Jun 30, 2011·International Journal of Trichology·Syed Yousuf Ali, Gurcharan Singh
Feb 18, 2016·Journal of Cancer Research and Therapeutics·Mutahir Ali TunioEyad Fawzi Al Saeed

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Citations

Sep 3, 2020·Archives of Endocrinology and Metabolism·Chandan Kumar JhaSaroj Kanta Mishra
Sep 15, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Huakang HuangAlexander Stessin
May 26, 2021·Archives of Endocrinology and Metabolism·Chandan Kumar JhaSaroj Kanta Mishra

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