Evaluation of tolerability and ability to increase immunosuppression in renal transplant patients converted from mycophenolate mofetil to enteric-coated mycophenolate sodium

Transplantation Proceedings
J-F BilodeauM Masse

Abstract

Dose reductions or discontinuations of mycophenolate mofetil (MMF) result in higher incidences of acute rejection and graft loss. Converting renal transplant patients experiencing MMF-related gastrointestinal (GI) side effects to equimolar enteric-coated mycophenolate sodium (EC-MPS) may relieve GI symptoms. In this prospective 12-month study, renal transplant patients maintained on suboptimal MMF doses (<1500 mg/d) due to GI intolerance were converted to equimolar EC-MPS followed by incremental EC-MPS dose increases (180 mg/d) every 7 weeks to an established maximum, if well tolerated. Changes in GI symptoms were assessed by physician judgment and Gastrointestinal Symptom Rating Scale (GSRS). Twenty-five patients (mean age: 52.0 +/- 13.6 years) were converted from MMF (930.0 +/- 153.4 mg/d) to equimolar EC-MPS (669.6 +/- 110.5 mg/d) at day 0. Twenty-three of 25 patients tolerated equimolar dose conversion and one or more EC-MPS dose increments at week 28. Compared to baseline, patients received significantly more EC-MPS at week 28 and week 49 (mean dose: 1033.0 +/- 164.8 mg/d, P < .0001 and 1001.7 +/- 209.0 mg/d, P < .0001, respectively). Two patients dropped out by week 7 for reasons unrelated to EC-MPS. The mean serum creati...Continue Reading

References

Jun 5, 2003·Clinical Transplantation·Ronald P PelletierRonald M Ferguson
Aug 26, 2003·Journal of the American Society of Nephrology : JASN·Greg A KnollCarl Van Walraven
Dec 12, 2003·The New England Journal of Medicine·Brian J NankivellJeremy R Chapman
Dec 26, 2003·The New England Journal of Medicine·Thomas A GonwaGoran B Klintmalm
Feb 21, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Maurizio SalvadoriUNKNOWN ERL B301 Study Groups
Feb 21, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Klemens BuddeUNKNOWN ERL B302 Study Group
Sep 15, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Leah KleinmanMary Kay Margolis
Sep 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S K TakemotoS Bunnapradist
Oct 3, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y Le MeurP Marquet
Apr 24, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Magdi ShehataChristopher Andrews

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Citations

May 6, 2014·Archives of Toxicology·Christine E Staatz, Susan E Tett
Nov 26, 2014·Transplantation Proceedings·E SavvidakiD S Goumenos
Aug 28, 2010·Expert Opinion on Drug Safety·Klemens BuddePetra Glander
Apr 19, 2018·Pediatric Annals·Swati SehgalDeepak Kamat

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