Evaluation of total hip arthroplasty devices using a total joint replacement registry

Pharmacoepidemiology and Drug Safety
Elizabeth W PaxtonArt Sedrakyan

Abstract

The purpose of this paper is to describe the infrastructure of the total joint replacement registry of a large integrated healthcare system's and emphasize challenges associated with orthopedic device classification and evaluation. Using a large integrated healthcare system innovative infrastructure including electronic health record data, administrative data sources, and registry data collection, we evaluated device choice and outcomes of total hip arthroplasty (THA). Devices were classified into type of bearing surface (alternative versus traditional). Multiple imputation was used to accommodate missing data, and a logistic regression model was applied to assess the impact of patient and surgeon factors on choice of bearing surface. A Cox regression model was used to evaluate risk of aseptic revision while controlling for surgeon, site, and patient characteristics. Adjusted cumulative probability-of-event curves were created, comparing survival of alternative against traditional bearings of devices, with aseptic revision as the outcome of interest. The study sample consisted of 25,377 primary THAs with an average follow-up of 2.7 years. Choice of bearing surface varied by surgeon and patient characteristics. After adjusting f...Continue Reading

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Citations

May 11, 2012·Pharmacoepidemiology and Drug Safety·Sebastian SchneeweissScott R Smith
Jul 24, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jingping Wu, Zhongxiao Peng
Sep 9, 2015·Veterinary Surgery : VS·Luca VezzoniRandy J Boudrieau
Jun 9, 2016·Veterinary Surgery : VS·Valerie E NesserRandy J Boudrieau
Jun 22, 2021·Expert Review of Medical Devices·Thibault DhalluinLeslie Grammatico-Guillon

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