Evaluation of total intravenous anesthesia with propofol or ketamine-medetomidine-propofol combination in horses

Journal of the American Veterinary Medical Association
Mohammed A UmarW W Muir

Abstract

Objective-To compare the anesthetic and cardiorespiratory effects of total IV anesthesia with propofol (P-TIVA) or a ketamine-medetomidine-propofol combination (KMP-TIVA) in horses. Design-Randomized experimental trial. Animals-12 horses. Procedure-Horses received medetomidine (0.005 mg/kg [0.002 mg/lb], IV). Anesthesia was induced with midazolam (0.04 mg/kg [0.018 mg/lb], IV) and ketamine (2.5 mg/kg [1.14 mg/lb], IV). All horses received a loading dose of propofol (0.5 mg/kg [0.23 mg/lb], IV), and 6 horses underwent P-TIVA (propofol infusion). Six horses underwent KMP-TIVA (ketamine [1 mg/kg/h {0.45 mg/lb/h}] and medetomidine [0.00125 mg/kg/h {0.0006 mg/lb/h}] infusion; the rate of propofol infusion was adjusted to maintain anesthesia). Arterial blood pressure and heart rate were monitored. Qualities of anesthetic induction, transition to TIVA, and maintenance of and recovery from anesthesia were evaluated. Results-Administration of KMP IV provided satisfactory anesthesia in horses. Compared with the P-TIVA group, the propofol infusion rate was significantly less in horses undergoing KMP-TIVA (0.14 +/- 0.02 mg/kg/min [0.064 +/- 0.009 mg/lb/min] vs 0.22 +/- 0.03 mg/kg/min [0.1 +/- 0.014 mg/lb/min]). In the KMP-TIVA and P-TIVA g...Continue Reading

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Citations

Sep 23, 2014·The Veterinary Journal·María VillalbaIgnacio A Gómez de Segura
Nov 9, 2010·The Veterinary Clinics of North America. Equine Practice·William W Muir
Jul 11, 2012·Journal of Veterinary Pharmacology and Therapeutics·A de VriesJ W Sear
Jun 26, 2014·Veterinary Anaesthesia and Analgesia·Cássia M Molinaro CoelhoLuiz Antonio F da Silva
Mar 17, 2010·Veterinary Anaesthesia and Analgesia·Fernando Sf CruzRenata Pb Steffen
Jul 6, 2014·Veterinary Anaesthesia and Analgesia·Tanya Duke-NovakovskiAndres F Sanchez-Teran
Dec 5, 2009·The Journal of Veterinary Medical Science·Kazuto YAMASHITAWilliam W MUIR
Oct 13, 2012·The Journal of Veterinary Medical Science·Tomohito IshizukaWilliam W Muir
Nov 21, 2014·The Journal of Veterinary Medical Science·Mohammed Ahmed UmarKazuto Yamashita
Sep 1, 2019·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Jessica L Siegal-WillottDavid L McRuer
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Miguel Gozalo-Marcilla, Simone Katja Ringer

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