PMID: 7529215Jan 1, 1994Paper

Evaluation of toxicity and efficacy of a combination of antineoplastic agents in the prevention of PVR

International Ophthalmology
M Salah-EldinM R Niesman

Abstract

The retinal toxicity of a combination of antineoplastic drugs in free and liposome-encapsulated form was determined in the rabbit eye. Bleomycin sulfate and 5-fluorouridine were evaluated by clinical observation, electroretinogram, and histological study. Forty-five eyes were injected with combinations of various doses of bleomycin and 5-FUR in free and encapsulated form; 10 eyes served as controls. The nontoxic free dose was found to be 3.5 micrograms bleomycin and 150 micrograms 5-FUR. Liposome encapsulation increased the nontoxic dose to 4.7 micrograms bleomycin and 200 micrograms 5-FUR. Four groups of rabbits in which proliferative vitreoretinopathy had been induced were used for the efficacy study; the control group received an injection of PBS; the second group was injected with a combination of 3.5 micrograms bleomycin and 150 micrograms 5-FUR in free form; the third group was injected with the identical doses in liposome-encapsulated form; and the fourth group received encapsulated bleomycin (4.7 micrograms) and 5-FUR (200 micrograms). The dose used in Group 4 was significantly more effective (P < 0.01) in preventing tractional retinal detachment and marginally more effective (P = 0.054) in preventing neovascularization.

References

Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·F Szoka, D Papahadjopoulos
Jul 15, 1987·American Journal of Ophthalmology·P WiedemannK Heimann
May 1, 1985·Survey of Ophthalmology·G A Peyman, J Schulman
Jan 1, 1980·American Journal of Ophthalmology·Y TanoR Machemer
Oct 1, 1982·American Journal of Ophthalmology·A OphirA J Claflin
Oct 1, 1982·American Journal of Ophthalmology·M S BlumenkranzA Hajek
Jul 1, 1983·American Journal of Ophthalmology·W H SternS K Fisher
Nov 1, 1981·American Journal of Ophthalmology·J F Weiss, M Belkin
Dec 1, 1980·American Journal of Ophthalmology·Y TanoR Machemer

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Citations

Aug 11, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Justus G GarwegDavid Goldblum
Mar 8, 2005·Survey of Ophthalmology·Shehab EbrahimPaul J Lee
Mar 8, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hsi-Kung KuoDan-Ning Hu
Apr 27, 2000·The British Journal of Ophthalmology·C H KonG W Aylward
Jan 29, 2010·Drugs & Aging·Noriyuki Kuno, Shinobu Fujii
Jul 26, 2015·Progress in Retinal and Eye Research·J Carlos PastorSantiago Delgado-Tirado
Jul 9, 2002·Eye·R H Y Asaria, Z J Gregor

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