PMID: 18203080Jan 19, 2008Paper

Evaluation of transforming growth factor and vascular endothelial growth factor polymorphisms in Taiwan Chinese patients with pterygium

European Journal of Ophthalmology
D-T BauF J Tsai

Abstract

Pterygium is an invasive and highly vascularized growth, thought to arise from activated and proliferating limbal epithelial stem cells. Epidemiologic studies have found the increase of active angiogenic and epithelial growth factors in pterygia, and implicated that these molecules could be involved directly or indirectly in the pathogenesis of pterygia as causative factors. The aim of this study was to investigate the association of polymorphisms of transforming growth factor (TGF) and vascular endothelial growth factor (VEGF) with pterygium. A total of 133 pterygium patients and 105 volunteers without pterygium were enrolled in this study. Polymerase chain reaction based restriction fragment length polymorphism analysis was used to resolve the TGF-Beta1-509 and VEGF-460 genotypes. There was no significant difference in the allele frequency or genotype of TGF-Beta1-509 or VEGF-460 between total pterygium and the control group. No interaction between TGF-Beta1-509 and VEGF-460 was found either. These results indicate that TGF-Beta1-509 and VEGF-460 polymorphisms were not highly associated with the pathology of pterygium. However, it may still be worthwhile to continue to search for angiogenic gene polymorphisms in order to pred...Continue Reading

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Citations

Oct 15, 2013·The British Journal of Ophthalmology·Mei-Ling PengYa-Wen Cheng
Nov 20, 2019·Investigative Ophthalmology & Visual Science·Hun LeeHungwon Tchah
Feb 12, 2010·The Journal of International Medical Research·H LuL L Zhu
Mar 5, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Lilla S SimonHyunjoo J Lee
Nov 9, 2010·Taiwanese Journal of Obstetrics & Gynecology·Chi-Chen ChangChih-Sheng Lin

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