Evaluation of transforming growth factor-beta 1 level in crevicular fluid of cyclosporin A-treated patients

Journal of Periodontology
N BuduneliGül Atilla

Abstract

The aim of the present study was to investigate the level of transforming growth factor-beta 1 (TGF-beta 1) in gingival crevicular fluid (GCF) samples of cyclosporin A (CsA)-treated patients and to compare the results with control groups. Fourteen renal transplant patients exhibiting severe CsA-induced gingival overgrowth, 10 patients with chronic gingivitis, and 10 subjects with clinically healthy periodontium were included in the study. In CsA-treated patients, GCF samples were harvested from sites exhibiting gingival overgrowth (CsA GO+) and sites not exhibiting gingival overgrowth (CsA GO-). The TGF-beta 1 levels in a total of 96 GCF samples from the 34 participants were analyzed by enzyme-linked immunosorbent assay. The results were expressed in terms of total amount (pg/2 sites) and concentration (ng/ml). TGF-beta 1 total amounts in CsA GO+ and CsA GO- sites were similar and significantly higher than that of healthy sites (P < 0.02 and P < 0.01, respectively). The total amount of TGF-beta 1 was also higher in gingivitis sites compared to the healthy sites, but the difference was not statistically significant (P > 0.05). CsA GO+ and CsA GO- sites exhibited higher total amount and concentration of TGF-beta 1 than that of gi...Continue Reading

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Citations

Feb 21, 2004·Journal of Periodontology·Nelson GnoattoMônica V Marquezini
Sep 16, 2004·Journal of Clinical Periodontology·J S EllisJ M Thomason
Oct 25, 2007·Journal of Periodontal Research·N GnoattoM V Marquezini
Mar 22, 2008·Journal of Clinical Periodontology·Małgorzata Radwan-OczkoTadeusz Dobosz
Jan 10, 2006·Periodontology 2000·P Mark Bartold, A Sampath Narayanan
Nov 12, 2014·Journal of Clinical Periodontology·Yi ChungCheng-Yang Chiang
Jun 10, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P C Trackman, A Kantarci
Feb 26, 2016·Journal of Dental Research·W H YangM Y P Kuo
Feb 7, 2004·The Annals of Otology, Rhinology, and Laryngology·Ryan C BranskiPatricia A Hebda
Apr 11, 2015·Journal of Dental Research·W H YangM Y P Kuo
May 26, 2006·Journal of Dental Research·H-J ChaeH-R Kim
Mar 17, 2009·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Patricia R CuryJosé Alexandre Barbuto
Jan 16, 2021·Journal of Periodontal Research·Yu-Tang ChinEarl Fu
Sep 29, 2021·Journal of Periodontal Research·Selman ÇelenCandeğer Avşar

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