Evaluation of treatment results in multifocal primary cutaneous anaplastic large cell lymphoma: report of the Dutch Cutaneous Lymphoma Group

The British Journal of Dermatology
Rutger C MelchersKoen D Quint

Abstract

There is no consensus on the treatment of multifocal primary cutaneous anaplastic large cell lymphoma (C-ALCL). Radiotherapy (RT) and methotrexate (MTX) are the current treatment options, but their efficacy is unknown. Recently, targeted therapies showed promising results in C-ALCL, and may therefore be an attractive first choice of treatment. To assess the efficacy of conventional treatment strategies for patients with multifocal C-ALCL, and to define which patients may require novel targeted therapies. In this multicentre study, treatment was evaluated in patients initially presenting (n = 24) or relapsing with multifocal C-ALCL (n = 17; 23 relapses). Distinction was made between patients with five or less lesions (n = 36) and more than five lesions (n = 11). Treatments most commonly used were RT (n = 21), systemic chemotherapy (n = 9) and low-dose MTX (n = 7) with complete response rates of 100%, 78% and 43%, respectively, and an overall response rate of 100%, 100% and 57%, respectively. Four patients showed complete spontaneous regression. In total, 16 of 24 patients (67%) first presenting with multifocal C-ALCL relapsed, including all five patients initially treated with CHOP (cyclophosphamide, hydroxydaunorubicin, oncovin...Continue Reading

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Citations

Sep 18, 2018·The British Journal of Dermatology·W Kempf
Jun 8, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R WillemzeUNKNOWN ESMO Guidelines Committee
Jan 10, 2020·International Journal of Dermatology·Roberta PiccinnoEmilio Berti
Jan 22, 2020·Minerva medica·Antonello SicaElvira Moscarella
Feb 6, 2020·International Journal of Environmental Research and Public Health·Antonello SicaCaterina Sagnelli
May 22, 2020·Current Hematologic Malignancy Reports·Cosimo Di RaimondoFarah R Abdulla
Oct 1, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R WillemzeUNKNOWN ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Jun 4, 2021·Clinical and Experimental Dermatology·H SarfrazS R K Pingali
May 5, 2021·Journal of the American Academy of Dermatology·Yuna OhSarah J Noor

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