Evaluation of trigeminal sensitivity to ammonia in asthmatics and healthy human volunteers.

Inhalation Toxicology
Maja PetrovaP Dalton

Abstract

Asthmatics often report the triggering or exacerbation of respiratory symptoms following exposure to airborne irritants, which in some cases may result from stimulation of irritant receptors in the upper airways inducing reflexive bronchoconstriction. Ammonia (NH3) is a common constituent of commercially available household products, and in high concentration has the potential to elicit sensory irritation in the eyes and upper respiratory tract of humans. The goal of the present study was to evaluate the irritation potential of ammonia in asthmatics and healthy volunteers and to determine whether differences in nasal or ocular irritant sensitivity to ammonia between these two groups could account for the exacerbation of symptoms reported by asthmatics following exposure to an irritant. Twenty-five healthy and 15 mild/moderate persistent asthmatic volunteers, with reported sensitivity to household cleaning products, were evaluated for their sensitivity to the ocular and nasal irritancy of NH3. Lung function was evaluated at baseline and multiple time points following exposure. Irritation thresholds did not differ between asthmatics and healthy controls, nor did ratings of odor intensity, annoyance, and irritancy following exposu...Continue Reading

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Citations

Sep 8, 2012·International Journal of Hygiene and Environmental Health·Peder Wolkoff
Jul 6, 2016·BioMed Research International·Christian MonséThomas Brüning
Aug 16, 2016·Chest·Susan M TarloUNKNOWN CHEST Expert Cough Panel
Jan 28, 2017·Environment International·Peder Wolkoff, Gunnar D Nielsen
Sep 4, 2014·Archives of Toxicology·Thomas BrüningChristoph van Thriel
Feb 25, 2017·Journal of Strength and Conditioning Research·Justin N VigilJ David Branch
Sep 13, 2019·Archives of Toxicology·Kirsten SuckerThomas Brüning
Nov 28, 2018·Journal of Strength and Conditioning Research·Justin N VigilJ David Branch
Jun 30, 2019·Brain and Behavior·Davide SattinUNKNOWN Coma Research Center, Fondazione IRCCS Istituto Neurologico “Carlo Besta”, Milan, Italy

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