Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorder

Neurobiology of Disease
Veronica ReinhartThomas A Lanz

Abstract

Brain-derived neurotrophic factor (BDNF) signaling is integral to a range of neural functions, including synaptic plasticity and exhibits activity-dependent regulation of expression. As altered BDNF signaling has been implicated in multiple psychiatric diseases, here we report a quantitative reverse transcription polymerase chain reaction (RT-PCR) analysis of mRNAs encoding TrkB, total BDNF, and the four most abundant BDNF transcripts (I, IIc, IV, and VI) in postmortem tissue from matched tetrads of subjects with schizophrenia, bipolar disorder, or major depressive disorder (MDD) and healthy comparison subjects. In all three regions examined, dorsolateral prefrontal cortex (DLPFC), associative striatum and hippocampus, total BDNF mRNA levels did not differ in any disease state. In DLPFC, BDNF IIc was significantly lower in schizophrenia relative to healthy comparison subjects. In hippocampus, BDNF I, IIc, and VI were lower in subjects with both schizophrenia and bipolar disorder relative to comparison subjects. In striatum, TrkB mRNA was lower in bipolar disorder and MDD, while BDNF IIc was elevated in MDD, relative to comparison subjects. These data highlight potential alterations in BDNF signaling in the corticohippocampal ci...Continue Reading

References

Jun 1, 1989·Neuron·Y A Barde
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·M KorteT Bonhoeffer
Mar 1, 1994·Current Biology : CB·A M Davies
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·M KorteT Bonhoeffer
Jan 1, 1997·Pharmacology, Biochemistry, and Behavior·J A SiuciakR M Lindsay
Mar 28, 1998·The European Journal of Neuroscience·S LinnarssonP Ernfors
Jun 26, 1998·Brain Research. Brain Research Reviews·B Connor, M Dragunow
Oct 12, 2001·Schizophrenia Research·N DuranyJ Thome
Jan 5, 2002·Synapse·Dean E DluzenJon M Walro
Feb 28, 2002·Nature Neuroscience·Andreas Meyer-LindenbergKaren Faith Berman
Jun 6, 2003·Progress in Neurobiology·Volkmar LessmannMarzia Malcangio
Sep 10, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ingrid Y C LiuRichard F Thompson
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Jan 14, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takanori HashimotoDavid A Lewis
Jan 19, 2005·Molecular Psychiatry·F AngelucciA A Mathé
Apr 6, 2005·Archives of General Psychiatry·Andreas S Meyer-LindenbergKaren Faith Berman
May 17, 2005·Brain Research. Molecular Brain Research·Félicien KaregeRomano La Harpe
May 23, 2006·Nature Reviews. Neuroscience·Henry H Yin, Barbara J Knowlton
Jul 18, 2006·Biological Psychiatry·David J PorteousJ Kirsty Millar
Mar 1, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francesca CalabreseMarco A Riva
Jul 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brooke H MillerMathew T Pletcher
Sep 21, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Keri Martinowich, Bai Lu
Mar 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kazuko SakataBai Lu
Oct 9, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzanne N Haber, Brian Knutson

❮ Previous
Next ❯

Citations

Oct 2, 2015·Schizophrenia Bulletin·Sohei KimotoDavid A Lewis
Aug 16, 2015·Behavioural Brain Research·M SchmidtP Gass
Sep 1, 2015·Neuroscience·R W Logan, C A McClung
Jul 30, 2015·Neurochemistry International·X Du, R A Hill
Jun 17, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·J LiJ Wang
May 12, 2016·Expert Opinion on Therapeutic Targets·Francesca CalabreseRaffaella Molteni
Aug 21, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xinming XieManxiang Li
Feb 15, 2019·Current Opinion in Psychiatry·Christin WeisslederCynthia Shannon Weickert
Jul 25, 2019·BMC Bioinformatics·Jinghang GuGuodong Zhou
Aug 22, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaolei ZhuAtsushi Kamiya
Jan 6, 2019·Pharmaceuticals·Ralf SchirrmacherVadim Bernard-Gauthier
Jun 18, 2017·Frontiers in Behavioral Neuroscience·Jana MurínováIgor Riečanský
Feb 21, 2018·Frontiers in Behavioral Neuroscience·Bianca PfaffensellerFábio Klamt
Aug 21, 2019·Oxidative Medicine and Cellular Longevity·José Rogério Souza-MonteiroMaria Elena Crespo-López
Aug 11, 2019·Nature Communications·Marianne L SeneyColleen A McClung
Apr 30, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Jia HuWanli Dong
Feb 24, 2020·Psychopharmacology·Bruno Lima GiacobboErik F J de Vries
Jul 26, 2017·Scientific Reports·Zhi-Kun QiuDa-Nian Wei
Aug 24, 2019·Frontiers in Cellular Neuroscience·Magdalena MirandaPedro Bekinschtein
May 22, 2020·Frontiers in Psychology·Claudia Savia GuerreraFilippo Caraci
Sep 28, 2020·Computers in Biology and Medicine·S T R Moolamalla, P K Vinod
Dec 18, 2020·Pharmacological Reviews·Antonio InserraGabriella Gobbi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.