PMID: 2498241Jun 1, 1989Paper

Evaluation of tumor energy metabolism and microvascular blood flow after glucose or mannitol administration using 31P nuclear magnetic resonance spectroscopy and laser Doppler flowmetry

International Journal of Radiation Oncology, Biology, Physics
P OkunieffL J Neuringer

Abstract

The effects of intraperitoneally administered glucose or mannitol (5 mg/g body weight, 25% solutions) on tumor energy metabolism and tumor red blood cell flux were studied using 31P-nuclear magnetic resonance spectroscopy and laser Doppler flowmetry. Isotransplants of a spontaneous murine fibrosarcoma growing in the hind foot dorsum were used. 31P-nuclear magnetic resonance and laser Doppler flowmetry studies in glucose treated animals were performed on small (congruent to 100 mm3) and large (congruent to 300 mm3) tumors. In mannitol treated animals, tumors with an average volume of congruent to 200 mm3 were used. Using this tumor model, intraperitoneally administration of the hypertonic sugar solutions caused similar declines in tumor microcirculation (mannitol, 60 +/- 8% flow reduction; glucose, 72 +/- 4% flow reduction; t = 60 min). These changes were not glucose-specific and can primarily be explained by a water shift into the abdominal cavity and an associated hypovolemic hemoconcentration. A stable (small tumors) or transiently increased (large tumors) tumor energy metabolism which occurred after glucose administration was probably caused by a transiently increased glucose availability. The decline in energy metabolism af...Continue Reading

References

Sep 1, 1989·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·F Kallinowski, P Vaupel
Jan 1, 1988·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·C Streffer
May 1, 1988·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·P VaupelM C Ambroz
Apr 1, 1987·International Journal of Radiation Oncology, Biology, Physics·A J ThistlethwaiteD B Leeper
Dec 1, 1987·International Journal of Radiation Oncology, Biology, Physics·J A KoutcherT Brady
Dec 1, 1987·American Journal of Clinical Oncology·P OkunieffH Suit
Dec 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J L Wike-HooleyH S Reinhold
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J L EvelhochJ J Ackerman
Apr 1, 1981·Bioscience Reports·J R GriffithsD Shaw

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Citations

Sep 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Z M BhujwallaJ D Glickson
Nov 1, 1993·NMR in Biomedicine·J D de CertainesO Henriksen
Feb 13, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·N ChoiP Kosmidis
Apr 30, 1994·International Journal of Radiation Oncology, Biology, Physics·K EnginJ D McFarlane
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H S ReinholdA P van den Berg
Jan 1, 1996·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·B C SchemO Dahl
Mar 1, 1995·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·K EnginJ D McFarlane
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·Z M BhujwallaJ D Glickson

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