Evaluation of tumor response after locoregional therapies in hepatocellular carcinoma: are response evaluation criteria in solid tumors reliable?

Cancer
Alejandro FornerJ Bruix

Abstract

Evaluation of response to treatment is a key aspect in cancer therapy. Response Evaluation Criteria in Solid Tumors (RECIST) are used in most oncology trials, but those criteria evaluate only unidimensional tumor measurements and disregard the extent of necrosis, which is the target of all effective locoregional therapies. Therefore, the European Association for the Study of the Liver (EASL) guidelines recommended that assessment of tumor response should incorporate the reduction in viable tumor burden. The current report provides an assessment of the agreement/concordance between both RECIST and the EASL guidelines for the evaluation of response to therapy. The authors evaluated a cohort of 55 patients within prospective studies, including 24 patients with hepatocellular carcinoma who underwent transarterial chemoembolization (TACE) with drug eluting beads (DEB-TACE) and 31 patients who underwent percutaneous ablation (percutaneous ethanol injection [PEI]/radiofrequency [RF]). Triphasic helical computed tomography scans were performed at baseline, at 1 month, and at 3 months after procedure, and 2 independent radiologists evaluated tumor response. Evaluating response according to RECIST criteria, no patients achieved a complet...Continue Reading

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References

Aug 1, 1990·Statistics in Medicine·E A Gehan, M A Schneiderman
Jan 1, 1981·Cancer·A B MillerA Winkler
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chung-Mau LoJohn Wong
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josep M Llovet, Jordi Bruix
Dec 31, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Rob J van KlaverenJan P van Meerbeeck
Feb 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J Byrne, A K Nowak
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Margarita SalaUNKNOWN Barcelona Clínic Liver Cancer Group
May 4, 2005·Journal of Hepatology·Calogero CammàUNKNOWN Unità Interdipartimentale Neoplasie Epatiche (U.I.N.E) Group
May 28, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P TherasseUNKNOWN EORTC Soft Tissue and Bone Sarcoma Group
Jun 14, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Anna K Nowak
Jul 15, 2005·The New England Journal of Medicine·Frances A ShepherdUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Howard I ScherGlenn Heller
Apr 18, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P TherasseJ Verweij
Apr 25, 2006·Nature Reviews. Cancer·Laura C Michaelis, Mark J Ratain
Jun 2, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P TherasseM Buyse
Jul 18, 2006·British Journal of Clinical Pharmacology·Shivaani KummarAnthony J Murgo
Feb 22, 2007·AJR. American Journal of Roentgenology·Ana L KeppkeFrank H Miller
Jun 1, 2007·The New England Journal of Medicine·Gary HudesUNKNOWN Global ARCC Trial
May 15, 2008·Journal of the National Cancer Institute·Josep M LlovetUNKNOWN Panel of Experts in HCC-Design Clinical Trials
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group

❮ Previous
Next ❯

Citations

Mar 22, 2012·European Journal of Nuclear Medicine and Molecular Imaging·V GohG J R Cook
Feb 1, 2011·Abdominal Imaging·Kyung Won KimByung Ihn Choi
May 18, 2011·Abdominal Imaging·Laura CrocettiRiccardo Lencioni
Sep 13, 2011·Abdominal Imaging·Carmen AyusoAngeles García-Criado
Jun 29, 2013·Abdominal Imaging·Yang GuoFrank H Miller
Dec 8, 2009·Cardiovascular and Interventional Radiology·Ahsun RiazRiad Salem
Nov 12, 2010·Cardiovascular and Interventional Radiology·Eleni Liapi, Jean-Francois H Geschwind
Aug 15, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Omar HyderTimothy M Pawlik
Jan 5, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Massimo Iavarone, Massimo Colombo
Mar 10, 2011·Nature Reviews. Clinical Oncology·Andrew X ZhuRakesh K Jain
Jul 27, 2010·Journal of Computer Assisted Tomography·Alampady Krishna Prasad ShanbhogueSrinivasa R Prasad
Mar 5, 2011·Journal of Gastroenterology and Hepatology·Min Ju KimJoong-Won Park
Dec 1, 2012·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·Shirin Elizabeth Khorsandi, Nigel Heaton
Apr 21, 2010·Annals of Surgical Oncology·Eleni Liapi, Jean-Francois H Geschwind
Jul 13, 2013·Annals of Surgical Oncology·Omar HyderTimothy M Pawlik
Aug 21, 2012·Biologics : Targets & Therapy·Christopher L Tinkle, Daphne Haas-Kogan
Sep 23, 2009·AJR. American Journal of Roentgenology·Christina SchramlMarius Horger
Jun 28, 2011·AJR. American Journal of Roentgenology·Vahid YaghmaiRiad Salem
Jul 26, 2013·AJR. American Journal of Roentgenology·Pedram RezaiVahid Yaghmai
Jun 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Richard L WahlMartin A Lodge
Oct 26, 2011·World Journal of Gastroenterology : WJG·Borja Hernández-BreijoLuis G Guijarro
Nov 22, 2013·World Journal of Gastroenterology : WJG·Marco VivarelliAndrea Risaliti
Oct 2, 2012·World Journal of Radiology·Ashwin RammohanPalaniappan Ravichandran
Dec 24, 2010·Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology·Yosuke YasudaKazunori Kihara
Apr 4, 2014·World Journal of Gastroenterology : WJG·Koichi HayanoDushyant V Sahani
Dec 23, 2011·Radiology·Riccardo Lencioni, Laura Crocetti
May 9, 2012·Medical Physics·Zachary H LevineClaus P Heussel
May 31, 2013·Future Oncology·Marcello MaidaCalogero Cammà

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