Evaluation of tumor shape variability in head-and-neck cancer patients over the course of radiation therapy using implanted gold markers

International Journal of Radiation Oncology, Biology, Physics
Olga Hamming-VriezeCoenraad Robert Nico Rasch

Abstract

This study quantifies tumor shape variability in head-and-neck cancer patients during radiation therapy using implanted markers. Twenty-seven patients with oropharyngeal tumors treated with (chemo)radiation were included. Helical gold markers (0.35 × 2 mm, 3-10/patient, average 6) were implanted around the tumor. Markers were identified on planning computed tomography (CT) and daily cone beam CT (CBCT). After bony anatomy registration, the daily vector length on CBCT in reference to the planning CT and daily marker movement perpendicular to the gross tumor volume (GTV) surface at planning CT (d(normal)) of each marker were analyzed. Time trends were assessed with linear regression of the <d(normal)>(markers). In 2 patients, 2 markers were implanted in normal tissue to evaluate migration by measuring intermarker distances. Marker implantation was feasible without complications. Three-dimensional vectors (4827 measurements, mean 0.23 cm, interquartile ratio 0.24 cm) were highest in base of tongue sublocalization (P<.001) and bulky tumors (vectors exceeded 0.5 cm in 5.7% [0-20 mL], 12.0% [21-40 mL], and 21.7% [≥ 41 mL], respectively [P<.001] of measurements). The measured inward time trend in 11/27 patients correlated with the vis...Continue Reading

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Citations

Oct 18, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peng JinTanja Alderliesten
Jun 5, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Marlen HaderleinOliver J Ott
Sep 12, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Simon van KranenJan-Jakob Sonke
Aug 26, 2014·International Journal of Radiation Oncology, Biology, Physics·Angelo MencarelliJan-Jakob Sonke
Jun 22, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Ruta ZukauskaiteJesper Grau Eriksen
Jan 16, 2014·Journal of Applied Clinical Medical Physics·Christoph HoffmannKristina Giske
Oct 28, 2019·Journal of Medical Imaging and Radiation Oncology·Stephen ChinAnanya Choudhury

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