Evaluation of ultrafast 2D NMR for quantitative analysis

Analytical Chemistry
Patrick GiraudeauSerge Akoka

Abstract

Recent ultrafast methods make it possible to obtain two-dimensional (2D) nuclear magnetic resonance (NMR) spectra in a fraction of a second. This paper presents the first evaluation of ultrafast 2D NMR for quantitative analysis. On the basis of optimized conditions presented in recent studies, two homonuclear ultrafast techniques, J-resolved spectroscopy and TOCSY, are evaluated on model mixtures in terms of repeatability, long time stability, and linearity. The results are compared to conventional 1D (1)H NMR spectroscopy. Repeatabilities better than 1% for ultrafast J-resolved spectra and better than 7% for TOCSY spectra are obtained. The long-term stability is better than 4% for J-resolved spectroscopy and between 2% and 11% for TOCSY. Moreover, both methods are characterized by excellent linearities. This new analytical method opens important perspectives for fast, precise, and accurate quantitative analysis of complex mixtures and for the quantitative study of short time scale phenomena.

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Citations

Jul 12, 2014·Annual Review of Analytical Chemistry·Patrick Giraudeau, Lucio Frydman
Dec 6, 2011·Journal of Magnetic Resonance·Meerakhan PathanPatrick Giraudeau
Sep 4, 2010·Journal of Pharmaceutical and Biomedical Analysis·Estelle MartineauSerge Akoka
Jun 1, 2010·Journal of Magnetic Resonance·Patrick Giraudeau, Serge Akoka
Nov 12, 2009·Phytochemical Analysis : PCA·Christian Ludwig, Mark R Viant
Feb 17, 2015·Journal of Advanced Research·Engy A Mahrous, Mohamed A Farag
Apr 1, 2011·Magnetic Resonance in Chemistry : MRC·Patrick Giraudeau, Serge Akoka
Jul 22, 2010·Magnetic Resonance in Chemistry : MRC·Clément PontoizeauLyndon Emsley
Apr 5, 2014·Magnetic Resonance in Chemistry : MRC·Patrick Giraudeau
Jan 26, 2013·Magnetic Resonance in Chemistry : MRC·Meerakhan PathanPatrick Giraudeau
Apr 1, 2015·Magnetic Resonance in Chemistry : MRC·Serge Akoka, Patrick Giraudeau
Jun 30, 2019·Metabolites·Abdul-Hamid EmwasDavid S Wishart
Jul 3, 2016·Magnetic Resonance in Chemistry : MRC·Patrick Giraudeau
Dec 6, 2014·The Journal of Organic Chemistry·María Encarnación Fernández-ValleAntonio Herrera
Dec 17, 2014·Analytical Chemistry·Renaud BoisseauMohammed Boujtita
Oct 27, 2011·Progress in Nuclear Magnetic Resonance Spectroscopy·James S McKenzieAdrian J Charlton

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