Abstract
The urinary concentration of 8-hydroxydeoxyguanine (8-OHdG), which is a biomarker of oxidative DNA damage, was measured in 248 healthy Japanese, and its correlations with life style, urinary metal elements, serum antioxidants, and other plasma or serum factors were investigated. The mean urinary concentration of 8-OHdG was 15.2+/-5.71 ng/mg creatinine. Mean urinary 8-OHdG was not significantly different in terms of age (<45, >or=45), gender, smoking (no, <20, >or=20), and alcohol consumption (no, occasionally, sometimes and usually). Moreover, multiple regression analysis showed a significant association between urinary 8-OHdG and urinary arsenic (As) or chromium (Cr), and a tendency for association between the former and aluminum (Al) and nickel (Ni). Age, gender and plasma or serum factors including antioxidants, lipid peroxide, HbA1c, BUN, and iron did not show such an association. The present study suggests that natural exposure to toxic metal elements such as As, Cr, and Ni may influence oxidative DNA damage in healthy people under usual environmental management. Therefore, the measurement of urinary metals such as As, Ni and Cr is prerequisite for the study of the relationship between urinary 8-OHdG and other variable fac...Continue Reading
References
Sep 1, 1978·Diabetes·E C AbrahamT H Huisman
Apr 1, 1976·Biochemical Medicine·K Yagi
Jan 16, 1992·Nature·H Maki, M Sekiguchi
Dec 1, 1992·Carcinogenesis·S LoftH E Poulsen
Nov 1, 1991·Chemical Research in Toxicology·K S Kasprzak
Jul 1, 1991·Analytical Biochemistry·K FrenkelJ J Solomon
Mar 1, 1990·Archives of Biochemistry and Biophysics·X G Shi, N S Dalal
Jan 1, 1986·Free Radical Research Communications·R A FloydR C Rickard
Feb 24, 1984·Nucleic Acids Research·H Kasai, S Nishimura
Jun 15, 1984·Toxicology and Applied Pharmacology·H Yamauchi, Y Yamamura
Jun 1, 1995·Free Radical Biology & Medicine·B YinR M Santella
Apr 10, 1995·Analytical Biochemistry·A J TeixeiraA P de Jong
Jan 10, 1995·Biochemistry·H HayakawaM Sekiguchi
Jan 1, 1994·Annual Review of Biochemistry·B Demple, L Harrison
Apr 22, 1993·Nature·T Lindahl
Feb 1, 1997·The American Journal of Clinical Nutrition·H PrieméH E Poulsen
Jul 1, 1998·The Science of the Total Environment·M A White, E Sabbioni
Nov 4, 1998·Nucleic Acids Research·T K HazraS Mitra
Dec 5, 1998·The Journal of Biological Chemistry·G DianovV A Bohr
Feb 19, 1999·Mutation Research·A A van ZeelandF Donato
Dec 11, 1999·Carcinogenesis·H J ThompsonC Conry
Mar 9, 2000·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Apr 15, 2000·Free Radical Research·M S CookeJ Lunec
Feb 7, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·C J SmithD J Doolittle
Jan 5, 2002·Industrial Health·R YoshidaY Ogawa
Jan 29, 2002·Free Radical Research·D GackowskiR Olinski
Mar 28, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·S CalzaA Decarli
Jun 8, 2002·Nephron·Masao KanauchiToshio Hashimoto
Aug 21, 2002·Circulation·Wim MartinetMark M Kockx
Oct 4, 2002·Free Radical Biology & Medicine·Joseph LunecMark D Evans
Dec 31, 2002·Toxicology·Wataru SakamotoSusumu Yukawa
Jan 1, 2003·Nutrition·Margareta KristensonChrister Tagesson
Jan 16, 2003·The Science of the Total Environment·B S IversenA Nicolotti
Feb 13, 2003·Mutation Research·Ruey-Hong WongTsun-Jen Cheng
Mar 7, 2003·Advances in Clinical Chemistry·Grzegorz Bartosz
Apr 30, 2003·Diabetes Care·Takeshi NishikawaEiichi Araki
Jul 18, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chiuan Chian ChiouJames T Wu
Jul 29, 2003·Occupational and Environmental Medicine·H W KuoF Y Wu
Sep 2, 2003·Mutation Research·Mark ToraasonHoward Wey
Oct 2, 2003·The Journal of Nutrition·Iman A HakimWendy Talbot
Oct 30, 2003·Free Radical Biology & Medicine·Masaru NakanoIkuhiro Yamasawa
Nov 25, 2003·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tadashi IgishiEiji Shimizu
Nov 26, 2003·Mutation Research·Jean CadetJean-Luc Ravanat
Mar 12, 2004·Nephrology·Shigeru AkagiHirofumi Makino
May 4, 2004·Environmental Health Perspectives·Jee Young KimDavid C Christiani
Jul 28, 2004·Toxicology and Applied Pharmacology·Hiroshi YamauchiMichael P Waalkes
Aug 4, 2004·Free Radical Biology & Medicine·Honglian ShiKe Jian Liu
Jan 5, 2005·BioFactors·Misao MiwaHirotomo Ochi
Jan 5, 2005·BioFactors·Setsuko KanayaHirotomo Ochi
Citations
Jun 2, 2007·Urological Research·Chanchai BoonlaPiyaratana Tosukhowong
May 25, 2012·Environmental Health and Preventive Medicine·Kimie SaitoYuka Iwasa
Aug 13, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Rani SauriasariKeiki Ogino
Jan 19, 2010·The Journal of Biological Chemistry·Takashi AsahiToshihiko Osawa
Jun 24, 2008·Nihon eiseigaku zasshi. Japanese journal of hygiene·Masahito AminakaKatsumi Yoshida
Jan 16, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Emel Calişkan-CanSevgi Yardim-Akaydin
Apr 15, 2008·Journal of Occupational Health·Noriyuki YoshiokaKazuyuki Omae
Mar 25, 2009·Journal of Clinical Biochemistry and Nutrition·Noriko SakanoKeiki Ogino
Jan 9, 2013·Inhalation Toxicology·Siva B PrasadHema M Prasad
Jan 16, 2016·Scandinavian Journal of Clinical and Laboratory Investigation·Pernille K Ellegaard, Henrik E Poulsen
Sep 18, 2013·Environment International·Adwoa A CommodoreLuke P Naeher
May 28, 2016·Environmental Science and Pollution Research International·Chung-Ching WangSaou-Hsing Liou
Jul 22, 2008·Toxicology and Applied Pharmacology·Yuanyuan XuGuifan Sun
Oct 13, 2006·Environmental Research·Chung-Yen LuFung-Chang Sung
Aug 13, 2014·Environmental Toxicology·Doha YahiaShuji Tsuda
Nov 4, 2008·Environmental Toxicology·You YangXiaoming Shen
Sep 4, 2012·Muscle & Nerve·Tomoo ManoGen Sobue
Jan 29, 2013·Journal of Separation Science·Shaowen ZhangLingshuang Cai
Feb 11, 2009·Free Radical Research·Noriko SakanoKeiki Ogino
Jun 10, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Tsukasa NakamuraHikaru Koide
Jan 13, 2010·Inhalation Toxicology·Sung Gu HanC Gary Gairola
Oct 15, 2010·Free Radical Research·Keiki OginoDa-Hong Wang
Mar 19, 2014·Electrophoresis·Xiangying MengYongsheng Ding
Feb 23, 2020·BMJ Open Respiratory Research·Shane Sakamaki-ChingPrue Talbot
Oct 24, 2018·PloS One·Liliya ChamitavaMaria E Zanolin
Feb 22, 2011·Bulletin of Environmental Contamination and Toxicology·Ilker AtesAsuman Karakaya
Jun 14, 2018·Experimental and Therapeutic Medicine·Yasuyo FukushiYasushi Mariya
Aug 4, 2009·Inhalation Toxicology·Ayako TakataKatsumi Yoshida
Sep 29, 2019·Ecotoxicology and Environmental Safety·Mengchen XuRutao Liu
Dec 3, 2020·Toxicology and Applied Pharmacology·Hiroshi Yamauchi, Ayako Takata
Aug 15, 2021·Environmental Geochemistry and Health·Ata RafieeMohammad Hoseini
Jan 27, 2010·Toxicology Letters·Paola ManiniAntonio Mutti
Nov 16, 2010·Free Radical Biology & Medicine·Roberta AndreoliGiuseppe De Palma
Jan 14, 2011·The Science of the Total Environment·Chi-Jung ChungYu-Mei Hsueh