Evaluation of Urinary Big Endothelin-1 in Feline Spontaneous CKD

Animals : an Open Access Journal From MDPI
M GiraldiPaola Scarpa

Abstract

The endothelin-1 (ET-1) system has been implicated in the development and progression of chronic kidney disease (CKD). No information on big ET-1 in feline urine is available. The purpose of this study was to evaluate if urinary big endothelin-1 (bigET-1) is associated with feline CKD. Sixty urine samples were prospectively collected from 13 healthy cats at risk of developing CKD and 22 cats with CKD of different International Renal Interest Society (IRIS) stages (1-4). Urinary bigET-1 was measured using a commercially available ELISA. BigET-1 normalized to urine creatinine (bigET-1:UC) was compared amongst stages and substages, as proposed by IRIS, and correlated with serum creatinine concentration, proteinuria and blood pressure. BigET-1:UC at the time of inclusion was compared between cats that remained stable and cats that progressed after 12 months. BigET-1:UC was significantly higher (p = 0.002) in cats at IRIS stages 3-4 (median: 21.9; range: 1.88-55.6), compared to all other stages, and in proteinuric (n = 8, median: 11.0; range: 0.00-46.4) compared with nonproteinuric cats (n = 38 median: 0.33; range: 0.00-55.6) (p = 0.029). BigET-1:UC was not associated with CKD progression. Urinary bigET-1 increased in advanced stage...Continue Reading

References

Dec 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C ZojaG Remuzzi
Jan 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D E Kohan
Mar 1, 1997·Veterinary Pathology·K A EatonM L Wellman
Oct 16, 1999·The Journal of Laboratory and Clinical Medicine·I CecioniG G Neri Serneri
Apr 6, 2001·Journal of Clinical Laboratory Analysis·H C ChenY H Lai
Mar 13, 2003·Kidney International·Giuseppe D'Amico, Claudio Bazzi
Dec 5, 2003·Veterinary Clinical Pathology·J P BraunA D J Watson
Dec 5, 2003·Veterinary Clinical Pathology·Alexander W BiondoPhilip F Solter
Jan 5, 2005·Bosnian Journal of Basic Medical Sciences·Emina Nakas-IćindićNesina Avdagić
Mar 17, 2006·Journal of the American Society of Nephrology : JASN·Neeraj DhaunDavid J Webb
Mar 13, 2009·American Journal of Physiology. Renal Physiology·Neeraj DhaunJane Goddard
Jan 7, 2010·Current Opinion in Nephrology and Hypertension·Donald E Kohan
Jan 22, 2011·The Veterinary Clinics of North America. Small Animal Practice·Harriet Syme
Jun 8, 2012·British Journal of Pharmacology·Neeraj DhaunDavid C Kluth
Jun 12, 2013·Journal of Veterinary Internal Medicine·C R SharpC R Reinero
Aug 1, 2013·The Veterinary Journal·Gabriele RossiSaverio Paltrinieri
Oct 8, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Agata KowalczykAnna Goraca
Dec 6, 2014·The Veterinary Journal·Jack LawsonRosanne Jepson
Mar 5, 2016·Journal of Feline Medicine and Surgery·Andrew H SparkesJessica Quimby
May 12, 2016·Kidney International·Brianna DufekDominic Cosgrove

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage
sedation
ELISA

Software Mentioned

GraphPad Prism
Graph
Excel
- Pad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Feline Medicine and Surgery
Brice S Reynolds, Hervé P Lefebvre
Journal of Feline Medicine and Surgery
Dominique Paepe, Sylvie Daminet
Journal of Feline Medicine and Surgery
Samantha Taylor, Andrew H Sparkes
© 2021 Meta ULC. All rights reserved