Evaluation of urinary metabolites of 1-nitropyrene as biomarkers for exposure to diesel exhaust in taxi drivers of Shenyang, China

Journal of Exposure Science & Environmental Epidemiology
Justin P Miller-SchulzeChristopher D Simpson

Abstract

Diesel exhaust (DE) is a significant contributor to the toxicity associated with particulate matter (PM). 1-Nitropyrene (1-NP) has been used as a molecular marker for DE, and the urinary metabolites of 1-NP have been proposed as biomarkers for exposure to DE. In this study, several urinary 1-NP metabolites were evaluated for their utility as markers of short-term exposures to DE. The study population was a cohort of 24 taxi drivers from Shenyang, China, who submitted urine samples collected before, after, and the next morning following their workshifts. The urinary metabolites studied were isomers of hydroxy-1-nitropyrene (3-, 6-, 8- OHNPs) and hydroxy-N-acetyl-1-aminopyrene (3-,6-, 8-OHNAAPs). Exposure to DE was estimated based on exposure to 1-NP in air samples collected during and after the driver's workshift; 6- and 8-OHNP, and 8-OHNAAP were consistently detected in the drivers' urine. Concentrations of the metabolites in the taxi drivers' urine were greater than metabolite levels previously reported in non-occupationally exposed subjects; however no associations were observed between subject-specific exposures to 1-NP and urinary metabolites measured at the end of the workshift or in the next morning void. Significant auto...Continue Reading

References

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Dec 31, 2009·Environmental Science & Technology·Justin P Miller-SchulzeChristopher D Simpson
May 6, 2010·Journal of Exposure Science & Environmental Epidemiology·Susan HuyckJunfeng Jim Zhang

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Citations

Dec 17, 2015·Journal of Exposure Science & Environmental Epidemiology·Vanessa Eileen GalavizChristopher David Simpson
Oct 27, 2015·Environmental Science & Technology·Jill K SchulteSheryl Magzamen
Aug 30, 2014·Critical Reviews in Environmental Science and Technology·David A Morgott
Oct 11, 2016·Biomedical Chromatography : BMC·Kazuichi HayakawaAkira Toriba
Jan 5, 2018·Annals of Work Exposures and Health·Erin A RileyChristopher D Simpson
May 24, 2021·The Science of the Total Environment·Agnieszka Krzyszczak, Bożena Czech
Sep 22, 2017·Chemical Research in Toxicology·Gabriele Sabbioni

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