PMID: 16646448May 2, 2006Paper

Evaluation of urinary methoxyphenols as biomarkers of woodsmoke exposure

Environmental Science & Technology
Russell L DillsChristopher D Simpson

Abstract

Urinary methoxyphenols have been proposed as biomarkers for woodsmoke exposure, but the relationship between exposure and urinary methoxyphenol concentrations has not been characterized. We collected personal particulate matter2.5 and urine samples from 9 adults experimentally exposed to smoke from an open wood fire to characterize this relationship. Personal exposures (PM2.5 mean 1500 microg/ m3) varied 3.5-fold. Twenty-two methoxyphenols, levoglucosan, and 17 polynuclear hydrocarbons were quantified by gas chromatography/mass spectrometry assays for personal filter samples and urine samples. Most methoxyphenols had measurable preexposure levels. Propylguaiacol, syringol, methylsyringol, ethylsyringol, and propylsyringol had peak urinary concentrations after the woodsmoke exposure. Eight subjects had peak urinary elimination of methoxyphenols within 6 h (t1/2 3-5 h), whereas one had delayed elimination. Several metrics for urinary excretion were evaluated. Analyte concentration was greatly affected by diuresis. Excretion rate and analyte concentrations normalized by creatinine gave a clearer signal and were equivalent in predictive ability. Twelve-hour average creatinine-normalized concentrations of each of the 5 methoxyphenol...Continue Reading

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Citations

Aug 27, 2009·Journal of Exposure Science & Environmental Epidemiology·Megan A BergauffChristopher P Palmer
Jan 24, 2009·Environmental Health Perspectives·Christopher T MigliaccioTony J Ward
Mar 5, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jamie RylanceWilliam J Martin
Jan 5, 2016·Environmental Science & Technology·Sujan FernandoDon Shaw
Mar 4, 2014·International Journal of Occupational and Environmental Health·Luke P NaeherChristopher D Simpson
Jan 22, 2015·Journal of Exposure Science & Environmental Epidemiology·Zheng LiChristopher D Simpson
Jun 14, 2017·Journal of Occupational and Environmental Hygiene·Matthew D FergusonTony Ward
Sep 7, 2018·Journal of Occupational and Environmental Medicine·Bridget PetersJohn C Quindry
Jan 6, 2018·The European Respiratory Journal·Akshay SoodJohn Balmes
Dec 31, 2009·Inhalation Toxicology·Maria T MorandiUNKNOWN Risk Assessment Workgroup
Oct 12, 2010·Drug Metabolism and Pharmacokinetics·Suzanne AbbasJacques Magdalou
Mar 10, 2017·Journal of the Air & Waste Management Association·Jorge JimenezJorge Yañez
Jan 9, 2010·Inhalation Toxicology·Christopher D Simpson, Luke P Naeher
Aug 28, 2021·Journal of Applied Toxicology : JAT·Xinwen ZhangChangqing Wu

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