Evaluation of urinary rapid test for Helicobacter pylori in general practice

Journal of Clinical Laboratory Analysis
T FujisawaF Machikawa

Abstract

There is increasing interest in noninvasive tests for the diagnosis of Helicobacter pylori (H. pylori) infection. One such test, a urine-based rapid test kit (RAPIRUN H. pylori Antibody, Otsuka Pharmaceutical Co., Ltd.) for detection of antibody to H. pylori, has been developed and is considered ideal. In addition to its noninvasiveness and safe handling-due to use of urine as a sample-the assay procedure used for the urinary rapid test is very simple. Only 10-20 minutes are required to complete an assay, and no instruments are needed. The aim of this study was to examine the clinical usefulness of this urine-based rapid test. A total of 189 patients, including 76 patients with gastroduodenal disease, were recruited. A pair of random single-void urine and serum samples was collected from each of the 189 patients, and antibody to H. pylori in the urine and serum samples was measured using the urine-based rapid test kit and three commercially available serum-based ELISA kits. For the patients with gastroduodenal disease, invasive diagnostic methods using endoscopic biopsy specimens such as culture, histology, and rapid urease test were also performed. The sensitivity, specificity, and accuracy of the urinary rapid test were evalu...Continue Reading

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Citations

Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Apr 28, 2005·International Journal of Clinical Practice·M SönmezogluS G Barut
Jan 31, 2013·Pediatrics International : Official Journal of the Japan Pediatric Society·Masumi OkudaYoshihiro Fukuda
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Jan 17, 2019·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Taher Mohammadian, Leila Ganji

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