PMID: 836018Jan 1, 1977

Evaluation of various analogues of tilorone hydrochloride against Venezuelan equine encephalitis virus in mice

Antimicrobial Agents and Chemotherapy
R W KuehneE L Stephen

Abstract

The antiviral activity of tilorone hydrochloride and three of its analogues (11,002, 11,567, and 11,877) was assessed by oral and intraperitoneal (i.p.) administration to Venezuelan equine encephalitis (VEE) virus-infected mice. Significant increases in the percentage of survival (P < 0.01) were apparent after oral administration of tilorone and analogue 11,877 at dosages of 250 and 500 mg/kg. Neither tilorone nor 11,877 increased percentage of survival when dosages of 31.25 to 500 mg/kg were given by the i.p. route. Orally administered analogue 11,002 was effective against 100 mouse intracranial median lethal doses (MICLD(50)) of VEE virus at doses at 250 to 1,000 mg/kg; doses of 31.25 to 250 mg/kg given i.p. were effective against 10 MICLD(50). Oral dosages of 250 to 1,000 mg of analogue 11,567 per kg were active against 100 MICLD(50) of virus. By the i.p. route, 250 mg of 11,567 per kg protected mice against 1,000 MICLD(50), and a dose of 125 mg/kg protected against 100 MICLD(50). Oral treatment of VEE infection with analogue 11,567 24 h after subcutaneous inoculation of VEE virus resulted in no significant increase in the percentage of survivors. All survivors of these studies were susceptible to rechallenge 21 days after t...Continue Reading

References

Feb 1, 1970·The Journal of Infectious Diseases·M R Hilleman
Jul 1, 1970·Archives of Internal Medicine·M R Hilleman
Sep 18, 1970·Science·R F Krueger, G D Mayer
Sep 18, 1970·Science·G D Mayer, R F Krueger
Oct 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·F F PindakP T Allen
Jan 1, 1972·Antimicrobial Agents and Chemotherapy·D J GironF F Pindak
May 2, 1970·Nature·T W Schafer, R Z Lockart
Feb 1, 1971·The Journal of Infectious Diseases·E De Clercq, T C Merigan
May 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·H E KaufmanD C Brown

Citations

Jan 1, 1981·Pharmacology & Therapeutics·E R Kern, L A Glasgow
Nov 15, 2017·Antimicrobial Agents and Chemotherapy·Sean EkinsPeter B Madrid
Mar 25, 2020·Antimicrobial Agents and Chemotherapy·Sean Ekins, Peter B Madrid

Related Concepts

Medicinal Plants Testing, Preclinical
Venezuelan equine encephalitis virus
Encephalomyelitis, Equine
Venezuelan Equine Encephalomyelitis
Fluorenes
Injections, Intraperitoneal
Tilorone

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.