Evaluation of wound-covering materials

Journal of Biomedical Materials Research
A D SchwopeW A Skornick

Abstract

Physical and in vivo (burned rat model) evaluations as wound coverings were performed for 1) a freeze-dried collagen/poly (epsilon-caprolactone) (PCL) film laminate, 2) a freeze-dried PCL "foam"/PCL film laminate, and 3) a heat-dried collagen/PCL film laminate. Porcine skin and cadaver skin were also evaluated in vivo for the purpose of comparison. Water-vapor transmission rates and Young's moduli were measured. The degree of adherence of the coverings to the wound were measured. Grafts which became significantly adherent (greater than 150 dyne/cm2) to the wound within 1 day were most successful in promoting the formation of a viable tissue bed which appeared ready to accept further grafting. The force required to remove the PCL foam laminate from a full-thickness excision wound was found to increase from 170 dyne/cm2 on the first day postgraft to 1500 dyne/cm2 by the tenth day. The force required to remove freeze-dried collagen laminate remained constant at 200 dyne/cm2 over the 10 day test period. For the heat-dried collagen laminate, a force of only 50 dyne/cm2 was required on day 1, increasing to 200 dyne/cm2 on day 6. Insensible water-loss rates of animals grafted with the laminates were found to be similar to those from a...Continue Reading

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Citations

May 1, 1988·Biomaterials·M F JonkmanA J Pennings
Aug 11, 2007·Journal of Biomaterials Science. Polymer Edition·Kee Woei NgDietmar W Hutmacher
Feb 6, 2004·Journal of Biomedical Materials Research. Part a·Kleber de Arruda AlmeidaJulio San Román
Jun 23, 2015·Scientific Reports·Ying ChenXue Feng
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Sasiprapa Chitrattha, Thawatchai Phaechamud
Sep 1, 1991·The Journal of Surgical Research·M ChvapilT Chvapil
Jun 1, 1987·Burns, Including Thermal Injury·D QueenW H Reid
May 26, 2006·International Wound Journal·Douglas QueenGeoff Sussman
Aug 5, 2020·Scientific Reports·Dalia Jane SaldanhaNoémie-Manuelle Dorval Courchesne
Dec 10, 1990·Clinical Materials·A NangiaH Maibach
Jan 1, 1981·Journal of Biomedical Materials Research·P M NeumannY Ehrenreich
May 1, 1982·Journal of Biomedical Materials Research·M Chvapil

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