Evaluation of Wound Dressing Made From Spider Silk Protein Using in a Rabbit Model

The International Journal of Lower Extremity Wounds
Zahra SetooniParviz Farzadinia

Abstract

The aim of the present article was to study the healing of wounds using spider silk. Eight New Zealand female rabbits were selected as animal model. First, 3 identical wounds with length of 15 mm and a depth of 4 mm on the back of each rabbit were created. The first group, as standard control, did not receive any special treatment, they were treated only with saline and Vaseline locally. The second group, as positive control, received a thin film of phenytoin 1% ointment locally. The third group, as treated group, received a thin film of spider silk protein. At the end of the study, a biopsy of skin was done. After tissue preparation, all sections were evaluated. Some morphometrical parameters such as counting cells, fibroblasts, blood vessels, determination of the area of the wound closure, necrotic tissue, speed of wound healing, and epidermal thickness were done, and for data statistical analysis, SPSS software and Excel software were used. The results of this study showed that spider silk dressing may benefit as a possible effect of nanoparticles in the test preparation in wound healing.

References

Mar 10, 2001·Academic Medicine : Journal of the Association of American Medical Colleges·P Talalay, P Talalay
Mar 30, 2001·Nature·F Vollrath, D P Knight
Nov 26, 2003·Burns : Journal of the International Society for Burn Injuries·M J MullerJ P Heggers
Jun 22, 2006·The Journal of Experimental Biology·Todd A Blackledge, Cheryl Y Hayashi
Sep 23, 2006·Journal of Cellular and Molecular Medicine·Christina AllmelingPeter M Vogt
Oct 7, 2006·The Medical Journal of Australia·Linda C TapsellKaren E Inge
Mar 28, 2007·International Journal of Surgery·Seyed V HosseiniHooman Yarmohammadi
May 15, 2007·Burns : Journal of the International Society for Burn Injuries·Ratree MaenthaisongChuenjid Kongkaew
Sep 14, 2007·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Brook O SwansonCheryl Y Hayashi
Feb 23, 2010·Burns : Journal of the International Society for Burn Injuries·Lu BaoyongLi Min
Dec 28, 2010·Biomaterials·Andreas LammelThomas Scheibel
Jul 26, 2011·Acta chirurgica Belgica·E El-AbdellatiR Van Hee
Jul 10, 2012·International Journal of Pharmaceutics·Sorada KanokpanontPornanong Aramwit
Apr 8, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Amrita ChaudharyJyotirmoy Chatterjee
May 25, 2016·The International Journal of Lower Extremity Wounds·Parviz FarzadiniaAfshar Bargahi
Oct 28, 2017·International Wound Journal·Jacqueline Jhhm VestjensSamantha Sl Holloway
Feb 10, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Maryam MomeniMarzieh Ebrahimi

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Citations

Dec 6, 2019·Acta Biomaterialia·Dimple Chouhan, Biman B Mandal
Jan 21, 2021·ACS Nano·Jan Johansson, Anna Rising

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Software Mentioned

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