Evaluation of Xpert MTB-RIF guided diagnosis and treatment of rifampicin-resistant tuberculosis in Indonesia: A retrospective cohort study

PloS One
Arto Yuwono SoerotoPhilip C Hill

Abstract

Rifampicin-resistant tuberculosis (RR-TB) is largely underdetected in Indonesia. Xpert MTB/RIF (Xpert) has recently been introduced, prioritizing patients at risk of RR-TB, followed by phenotypic drug-susceptibility (DST) if rifampicin resistance is detected. This study investigated Xpert-based management of presumptive RR-TB cases under routine practice in West Java, Indonesia. We examined all records of patients tested with Xpert in the referral hospital for West Java in 2015-2016. We measured loss across a limited cascade of care, time to Xpert diagnosis and the commencement of initial second-line treatment, and identified factors associated with diagnostic and treatment delay. Additionally, we analyzed the appropriateness of treatment according to DST results. Of 3415 patients with presumptive RR-TB, 3215 (94%) were tested by Xpert, of whom 339 (10.5%) were diagnosed as RR-TB. 288 (85%) of 339 RR-TB patients started initial second-line TB treatment, with 48 (14%) patients being lost between diagnosis and pre-treatment assessment. Second-line treatment was commenced at a median of 41 days (IQR 29-70) after RR-TB diagnosis. Delays in both diagnosis and treatment initiation were observed in 104 (52%) of 201 RR-TB patients with...Continue Reading

Associated Clinical Trials

References

Jul 13, 2000·Lancet·A Van RieP D Van Helden
Feb 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN Infectious Diseases Society of America
Nov 14, 2008·Archivos de bronconeumología·Domingo J PalmeroJosé A Caminero Luna
Jan 24, 2009·The European Respiratory Journal·K Kliiman, A Altraja
Mar 31, 2010·Clinical Journal of Oncology Nursing·Jane GriffithLeslie J Blackhall
Sep 21, 2010·Journal of Bodywork and Movement Therapies·Waldemar AndrzejewskiKatarzyna Cymer
Oct 5, 2010·Journal of Lower Genital Tract Disease·Yannis M PaulusMary T Jacobson
Jan 31, 2012·BMJ : British Medical Journal·Ganapati Mudur
Jun 8, 2012·The New England Journal of Medicine·Yanlin ZhaoYu Wang
Oct 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Karen R JacobsonRobin M Warren
Apr 12, 2013·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·M M ClaassensM W Borgdorff
Jun 14, 2013·Journal of Clinical Microbiology·Armand Van DeunBouke C de Jong
Aug 7, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Songhua ChenWei Ma
Aug 9, 2013·The American Journal of Tropical Medicine and Hygiene·Amal BassiliErnesto Jaramillo
Jan 5, 2014·BMC Infectious Diseases·Jacob CreswellLucica Ditiu
Feb 15, 2014·The European Respiratory Journal·Sandra V KikMadhukar Pai
Apr 11, 2014·The Lancet. Respiratory Medicine·Keertan DhedaRobin Warren
Mar 15, 2015·The Journal of Infectious Diseases·Madhukar Pai, Marco Schito
Sep 18, 2015·Lancet·Keertan DhedaGary Maartens
Nov 26, 2015·The Lancet. Respiratory Medicine·Emily A KendallDavid W Dowdy
Nov 29, 2015·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·N LorentL Lynen
Mar 12, 2016·International Journal of Mycobacteriology·CucunawangsihNata Pratama Hardjo Lugito
Mar 13, 2016·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·S TahseenM Zignol
Mar 24, 2016·BMC Medicine·Laura J MartinDavid A J Moore
Oct 28, 2016·Nature Reviews. Disease Primers·Madhukar PaiMario Raviglione
Oct 31, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Danielle CazabonMadhukar Pai
Oct 19, 2017·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·R BoydH Cox

❮ Previous
Next ❯

Citations

Mar 3, 2020·Wellcome Open Research·Darma ImranUNKNOWN Tuberculous Meningitis International Research Consortium
Mar 3, 2020·Wellcome Open Research·James A SeddonUNKNOWN Tuberculous Meningitis International Research Consortium
Apr 8, 2021·Microbiology·Leah Isobella Rankine-WilsonYossef Av-Gay
Jun 2, 2021·International Journal of Surgery Case Reports·Sally MahdianiRiri Handayani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
G KurbaniyazovaF Luelmo
The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
N LorentLutgarde Lynen
© 2022 Meta ULC. All rights reserved