Evaluation of Xpert MTB/RIF for the Diagnosis of Lymphatic Tuberculosis.

BioMed Research International
Hou-He LiXu-Guang Guo

Abstract

The World Health Organization approved the use of Xpert MTB/RIF for the detection of Mycobacterium tuberculosis DNA, which has significantly improved the diagnosis of tuberculosis. In this study, our main objective was to evaluate the diagnostic efficacy of Xpert MTB/RIF for lymphoid tuberculosis to determine whether Xpert MTB/RIF could be used as a routine detection method. We searched four databases for the relevant literature published from May 2007 to December 2019. The quality of the literature was evaluated with reference to the evaluation criteria. Data that were extracted from the literature on Xpert MTB/RIF diagnosis of lymphatic tuberculosis were used to plot the summary receiver operating characteristic (SROC) curve, after which the software was used to combine and analyze the accuracy of these data. A total of 27 studies were included. The sensitivity of Xpert MTB/RIF for detecting lymphatic tuberculosis was 0.79 (95% CI (0.77, 0.81)), the specificity was 0.88 (95% CI (0.87, 0.90)), and the positive likelihood ratio (PLR) was 7.21 (95% CI (4.93, 10.55)). In addition, the negative likelihood ratio (NLR) was 0.25 (95% CI (0.19, 0.32)) and the diagnostic odds ratio (DOR) was 40.23 (95% CI (24.53, 65.98)). At the same t...Continue Reading

References

Sep 10, 2010·The New England Journal of Medicine·Catharina C BoehmeMark D Perkins
Jan 29, 2011·Journal of Clinical Microbiology·Doris HillemannElvira Richter
Mar 15, 2011·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·B MalbrunyV Cattoir
May 20, 2011·Journal of Clinical Microbiology·Viral VadwaiCamilla Rodrigues
Jun 10, 2011·Journal of Clinical Microbiology·Manuel CausseManuel Casal
Sep 2, 2011·Journal of Clinical Microbiology·Louis J LigthelmColleen A Wright
Jan 14, 2012·The European Respiratory Journal·Enrico TortoliDaniela M Cirillo
May 11, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A Van RieC N Menezes
Oct 30, 2013·The Laryngoscope·Yuria Ablanedo-TerrazasGustavo Reyes-Terán
Mar 7, 2014·Annals of the American Thoracic Society·Devesh J DhasmanaOnn Min Kon
Nov 2, 2014·The Pediatric Infectious Disease Journal·Liezel CoetzeeColleen A Wright
Feb 17, 2015·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·E PenzM T James
Dec 17, 2015·Tropical Medicine & International Health : TM & IH·Shirly SuzanaJoy S Michael
Feb 24, 2016·The Journal of Clinical Investigation·Thomas R LernerMaximiliano G Gutierrez
Mar 12, 2016·International Journal of Mycobacteriology·Asma GharianiLeila Slim-Saidi
Jun 12, 2016·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·G NatarajP Mehta
Jan 6, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David M LewinsohnGail L Woods
Feb 16, 2018·Journal of Tropical Pediatrics·Betsy RebeccaWinsley Rose
Mar 28, 2018·Public Health Action·M GidadoJ Kuye
Apr 28, 2018·Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·Y J QuS Y Zhan
Aug 28, 2018·The Cochrane Database of Systematic Reviews·Mikashmi KohliKaren R Steingart
Sep 12, 2018·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Samreen SarfarazNaseem Salahuddin

❮ Previous
Next ❯

Methods Mentioned

BETA
nucleic acid amplification
PCR

Software Mentioned

meta
disc
Stata
Xpert

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Lancet
Giovanni FerraraMarkus Maeurer
Lancet
Fulvio SalvoDaniela Maria Cirillo
© 2021 Meta ULC. All rights reserved