Evans Blue Dye: A Revisit of Its Applications in Biomedicine.

Contrast Media & Molecular Imaging
Linpeng YaoFeng Chen

Abstract

Evans blue (EB) dye has owned a long history as a biological dye and diagnostic agent since its first staining application by Herbert McLean Evans in 1914. Due to its high water solubility and slow excretion, as well as its tight binding to serum albumin, EB has been widely used in biomedicine, including its use in estimating blood volume and vascular permeability, detecting lymph nodes, and localizing the tumor lesions. Recently, a series of EB derivatives have been labeled with PET isotopes and can be used as theranostics with a broad potential due to their improved half-life in the blood and reduced release. Some of EB derivatives have even been used in translational applications in clinics. In addition, a novel necrosis-avid feature of EB has recently been reported in some preclinical animal studies. Given all these interesting and important advances in EB study, a comprehensive revisiting of EB has been made in its biomedical applications in the review.

References

Apr 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O UyamaM Sugita
Oct 1, 1966·Journal of Neuropathology and Experimental Neurology·O Steinwall, I Klatzo
Aug 1, 1974·Agents and Actions·M GigerG Zbinden
Dec 1, 1966·Acta Medica Scandinavica·U Abildgaard
Apr 1, 1993·Neuropathology and Applied Neurobiology·T Moos, K Møllgård
Oct 23, 1997·The Journal of Cell Biology·V StraubK P Campbell
Aug 7, 1999·Journal of the American College of Surgeons·S S BassD S Reintgen
Sep 24, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Y BobinP Roy
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·K M KurrelmeyerD L Mann
Nov 5, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Michel SlamaEdward D Frohlich
Mar 18, 2003·International Immunopharmacology·Hiroshi MaedaYasunori Kitamoto
Nov 1, 1955·Circulation Research·W W LACYE V NEWMAN
Jun 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·H A DAVISL H GIBSON
Sep 1, 1958·Journal of Clinical Pathology·M HOBSLEY, E D DEW
Mar 1, 1959·Journal of Clinical Pathology·A C LAWRENCE, G WALTERS
Jan 1, 1960·Annual Review of Physiology·E B REEVEJ E ROBERTS
Sep 1, 1951·The Journal of Clinical Investigation·A C WITHAMW L BLOOM
Apr 1, 2005·Nature·Heather StantonAmanda J Fosang
Jul 19, 2005·Investigative Radiology·Yicheng NiGuy Marchal
Nov 15, 2005·Neurosurgery·Tomoko OzawaMitchel S Berger
Aug 18, 1942·The Journal of Physiology·A C Crooke, C J Morris
Nov 20, 1897·The Journal of Physiology·G N Stewart
Mar 27, 1914·Science·H M Evans, W Schulemann
Jan 1, 2008·Journal of Immunological Methods·Maria I HarrellAlanna Ruddell

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Citations

Nov 8, 2018·Journal of Neuroinflammation·Yuan TangMohammad F Kiani
Dec 25, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Sumedha MukherjeeRanjana Patnaik
Aug 7, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Midori YoshiharaMakoto Inoue
Sep 22, 2019·International Journal of Molecular Sciences·Baruh PolisAbraham O Samson
Jun 15, 2019·Scientific Reports·Dirk F van HeldenGeoffrey K Isbister
Jun 27, 2019·Drug Delivery and Translational Research·Monique Culturato Padilha MendonçaMarcelo Bispo de Jesus
Sep 11, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yuankai LiuJunping Kou
May 2, 2019·Frontiers in Neurology·Natália Ferreira MendesLuciana Le Sueur-Maluf
Jan 8, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Yesen LiZhen Cheng
Oct 10, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Samantha R SlikboerJohn F Valliant
Dec 19, 2020·BioTechniques·Samuel E Honeycutt, Lori L O'Brien
Jun 21, 2020·Cancer Letters·Maria V BabakIrina V Balyasnikova
Feb 19, 2021·Military Medical Research·Yun-Fei LaiRui-Yun Peng
Aug 11, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohammad AbdallahNatalie L Trevaskis
Mar 2, 2021·American Journal of Physiology. Renal Physiology·Lipeng ChenBenkang Shi
May 8, 2021·Experimental Biology and Medicine·Noah Trac, Eun Ji Chung
May 28, 2021·Methods and Applications in Fluorescence·Michael C LarsonJennifer K Barton
Jun 3, 2021·International Journal of Molecular Sciences·Wei-Lin LoMing-Hsin Li
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Leidy D Ardila-LealBalkys E Quevedo-Hidalgo
Jan 16, 2021·ACS Biomaterials Science & Engineering·Jie WangHao Wang

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Methods Mentioned

BETA
fluorescence microscopy
biopsy
imaging techniques

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