PMID: 3748614Aug 1, 1986Paper

Evasion of macrophage microbicidal mechanisms by mature sporozoites of Plasmodium yoelii yoelii

Parasitology
J E Smith, J Alexander

Abstract

Sporozoites of Plasmodium yoelii yoelii were incubated for 40 min with BALB/c peritoneal macrophages in the presence of nitro-blue tetrazolium (NBT). While immature oocyst sporozoites triggered the macrophage respiratory burst, as visualized microscopically by the localized reduction of NBT to insoluble formazan, 97.6% of mature salivary gland sporozoites did not induce such a response. The macrophage oxidative response was also induced by 82.7% of heat-inactivated and 95.7% of trypsin-treated salivary gland sporozoites. The relationship of these results to the infectivity and immunogenicity of malarial sporozoites is discussed.

References

Jul 1, 1985·The Journal of Experimental Medicine·J M BlackwellS Gordon
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Dec 1, 1983·The Journal of Experimental Medicine·S D Wright, S C Silverstein
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Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·D P Turner

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Citations

Nov 1, 1990·The Journal of protozoology·J P VanderbergM J Stewart
Oct 8, 2004·Molecular Microbiology·Patricia Baldacci, Robert Ménard
Jun 16, 2015·Frontiers in Microbiology·Ute Frevert, Urszula Krzych
Jun 19, 2007·Cellular Microbiology·Ivan UsyninUte Frevert

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