Evasion of the human innate immune system by dengue virus.

Immunologic Research
Sarah Pagni, Ana Fernandez-Sesma

Abstract

Dengue virus is a worldwide health problem, with billions of people at risk annually. Dengue virus causes a spectrum of diseases, namely dengue fever, dengue hemorrhagic fever and dengue shock syndrome with the latter two being linked to death. Understanding how dengue is able to evade the immune system and cause enhanced severity of disease is the main topics of interest in the Fernandez-Sesma laboratory at Mount Sinai School of Medicine. Using primary human immune cells, our group investigates the contribution of dengue virus-specific proteins to the evasion of innate immunity by this virus and the host factors that the virus interacts with in order to evade immune recognition and to establish infection in humans. Here, we review recent findings from our group as well as published data from other groups regarding immune modulation by dengue virus.

References

Sep 1, 1981·The American Journal of Tropical Medicine and Hygiene·P ChiewsilpN Bhamarapravati
May 1, 1997·The American Journal of Tropical Medicine and Hygiene·S TheinJ Aaskov
Jul 17, 1998·Clinical Microbiology Reviews·D J Gubler
Dec 16, 1998·Journal of Virology·A J Johnson, J T Roehrig
Sep 29, 1999·Journal of Medical Virology·S GreenF A Ennis
Dec 23, 1999·The Journal of Infectious Diseases·D W VaughnA Nisalak
May 10, 2002·The Journal of Infectious Diseases·Daniel H LibratyAlan L Rothman
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Iva ZivnaAlan L Rothman
Sep 13, 2002·The American Journal of Tropical Medicine and Hygiene·William B MesserAravinda M De Silva
Aug 2, 2003·Emerging Infectious Diseases·Pallavi GargO Colin Stine
Aug 6, 2003·Emerging Infectious Diseases·William B MesserAravinda M de Silva
Nov 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jorge L Muñoz-JordanAdolfo García-Sastre
Jan 1, 1952·The American Journal of Tropical Medicine and Hygiene·A B SABIN
Apr 14, 2005·Journal of Virology·Meleri JonesMichael Jacobs
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ling-Jun HoJenn-Haung Lai
Jun 16, 2005·Journal of Virology·Jorge L Muñoz-JordánAdolfo García-Sastre
Sep 30, 2005·International Journal of Experimental Pathology·Alberto Yairh Limon-FloresLeopoldo Flores-Romo
Nov 16, 2006·Archives of Virology·B de la C SierraM G Guzmán
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ana P GoncalvezChing-Juh Lai
Nov 17, 2007·Cell Host & Microbe·Theodore C PiersonMichael S Diamond
Dec 1, 2007·Nature Reviews. Drug Discovery·Ernest C BordenGeorge R Stark
Feb 15, 2008·Journal of Virology·Kobporn BoonnakMary A Marovich
Feb 26, 2009·FEMS Immunology and Medical Microbiology·Umesh C Chaturvedi, Rachna Nagar
Mar 13, 2009·Journal of Virology·Joseph AshourAdolfo García-Sastre
Apr 28, 2009·The Journal of Infectious Diseases·Sasijit VejbaesyaHenry A F Stephens
Jun 19, 2009·Journal of Virology·Javier Mota, Rebeca Rico-Hesse
Oct 6, 2009·Current Topics in Microbiology and Immunology·Timothy P EndyMammen P Mammen
Nov 3, 2009·Gastroenterology·Christoph Welsch, Stefan Zeuzem
Nov 26, 2009·The Journal of Infectious Diseases·Angel BalmasedaEva Harris
Jan 12, 2010·PLoS Pathogens·Izabela A Rodenhuis-ZybertJolanda M Smit

❮ Previous
Next ❯

Citations

Jun 27, 2013·Journal of Biomedical Science·Tsung-Ting TsaiChiou-Feng Lin
May 6, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Sergio Isaac De La Cruz HernándezRosa María Del Angel
Jun 14, 2016·Advances in Virology·John F Arboleda, Silvio Urcuqui-Inchima
Jul 7, 2016·Virus Research·Higo Fernando Santos SouzaSilvia Beatriz Boscardin
May 8, 2016·Journal of Medical Virology·Jieying PuXi Huang
Mar 5, 2020·Molecular Biology Reports·Francesca RombiSharon Yeoh
May 27, 2020·Journal of Immunology Research·Patricio L AcostaLaura B Talarico
Jan 24, 2020·Science Translational Medicine·Steven R BrydenClive S McKimmie
Sep 16, 2020·International Journal of Cardiology·Chintan ShahChandrasekharan C Kartha
Sep 2, 2021·Saudi Journal of Biological Sciences·Mernan Jamal SabirSabah Mohmoud Hassan
Oct 12, 2021·PLoS Neglected Tropical Diseases·Jorge Andrés CastilloSilvio Urcuqui-Inchima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.