Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1

R M El-SayedM F El-Azab


Rheumatoid arthritis is a chronic inflammatory disease characterized by overproduction of inflammatory mediators along with undermined oxidative defensive mechanisms. Pathological angiogenesis was found to play a critical role in the progression of this disease. The current study was carried out to evaluate the anti-angiogenic, anti-inflammatory, and anti-oxidant effects of evening primrose oil (EPO), rich in gamma linolenic acid (GLA), either alone or in combination with aspirin or celecoxib, on adjuvant-induced arthritis. Arthritis was induced by subcutaneous injection of complete Freund's adjuvant (CFA) in the right hind paw of male albino rats. All treatments were administered orally from day 0 (EPO, 5 g/kg b.w.) or day 4 (celecoxib, 5 mg/kg; aspirin, 150 mg/kg) till day 27 after CFA injection. In the arthritic group, the results revealed significant decrease in the body weight and increase in ankle circumference, plasma angiopoietin-1 (ANG-1) and tumor necrosis factor-alpha (TNF-α) levels. Anti-oxidant status was suppressed as manifested by significant decline in reduced glutathione content along with decreased enzymatic activity of superoxide dismutase and increased lipid peroxidation. Oral administration of EPO exerted n...Continue Reading


Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jun 1, 1989·Clinical Rheumatology·J JänttiH Isomäki
Jan 31, 1972·Biochemical and Biophysical Research Communications·M NishikimiK Yagi
Jan 1, 1981·Progress in Lipid Research·S L KunkelR B Zurier
May 1, 1996·Arthritis and Rheumatism·M M HalloranA E Koch
Oct 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N MatsuoM Sugano
Jun 17, 1998·Arthritis and Rheumatism·A E Koch
Aug 26, 1999·Life Sciences·J P De La CruzF Sánchez de la Cuesta
Dec 2, 1999·Nature Medicine·N Ferrara, K Alitalo
Oct 29, 2000·Annals of the Rheumatic Diseases·A E Koch
Apr 12, 2001·Arthritis Research·D A Walsh, C I Pearson
Apr 20, 2001·Arthritis and Rheumatism·W P Arend
Jul 12, 2002·Arthritis Research·Ewa M Paleolog
Sep 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Li MaJohn L Wallace
Feb 8, 2003·Endothelium : Journal of Endothelial Cell Research·James R Stone, Tucker Collins
Feb 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Elliot D RosensteinGregory Kazandjian
Jul 16, 2003·Cellular and Molecular Life Sciences : CMLS·C Rüegg, A Mariotti
Aug 9, 2003·Springer Seminars in Immunopathology·Berent J PrakkenWillem van Eden
Sep 18, 2003·Osteoarthritis and Cartilage·Y E HenrotinJ-P L Pujol
Feb 27, 2004·Biochimica Et Biophysica Acta·Curzio RüeggAgnese Mariotti
Aug 24, 2006·Science's STKE : Signal Transduction Knowledge Environment·Masuko Ushio-Fukai
Nov 24, 2006·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·X CaiL Liu
Jun 15, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Gaëlle ClavelMarie-Christophe Boissier
Oct 31, 2007·Nature Clinical Practice. Rheumatology·Zoltán Szekanecz, Alisa E Koch
Apr 15, 2010·Arthritis Care & Research·Irving KushnerMarina Magrey
Jun 8, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Enrique ChávezPablo Muriel
Aug 12, 2010·International Journal of Radiation Biology·Mona A El-GhazalyMohamed T Khayyal

❮ Previous
Next ❯


Apr 22, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Kewen ZhengWanli Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here