Event-driven time-optimal control for a class of discontinuous bioreactors

Biotechnology and Bioengineering
Jaime A MorenoIván Moreno-Andrade

Abstract

Discontinuous bioreactors may be further optimized for processing inhibitory substrates using a convenient fed-batch mode. To do so the filling rate must be controlled in such a way as to push the reaction rate to its maximum value, by increasing the substrate concentration just up to the point where inhibition begins. However, an exact optimal controller requires measuring several variables (e.g., substrate concentrations in the feed and in the tank) and also good model knowledge (e.g., yield and kinetic parameters), requirements rarely satisfied in real applications. An environmentally important case, that exemplifies all these handicaps, is toxicant wastewater treatment. There the lack of online practical pollutant sensors may allow unforeseen high shock loads to be fed to the bioreactor, causing biomass inhibition that slows down the treatment process and, in extreme cases, even renders the biological process useless. In this work an event-driven time-optimal control (ED-TOC) is proposed to circumvent these limitations. We show how to detect a "there is inhibition" event by using some computable function of the available measurements. This event drives the ED-TOC to stop the filling. Later, by detecting the symmetric event,...Continue Reading

References

Jun 7, 2003·Biotechnology Progress·Der-Ming Chang

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Citations

Oct 3, 2007·Bioprocess and Biosystems Engineering·Manuel J BetancurDenis Dochain
Feb 14, 2013·Bioprocess and Biosystems Engineering·Térence Bayen, Francis Mairet

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