Event-related fMRI of myoclonic jerks arising from dysplastic cortex

Epilepsia
John S ArcherGraeme D Jackson

Abstract

Malformations of cortical development can cause epileptiform activity and myoclonic jerks, yet EEG correlates of jerks can be difficult to obtain. We studied a woman who had frequent episodes of persistent right-foot jerking since childhood. Ictal and interictal EEG had shown no localizing epileptiform activity. Functional imaging experiments were performed with concurrent video monitoring to document the timing of foot jerks. These studies mapped brain regions controlling voluntary right- and left-foot movements, and spontaneous right-foot jerks. High-resolution structural MR imaging revealed a dysplastic gyrus extending anteriorly off the left central sulcus. Event-related analysis of spontaneous jerks revealed prominent activation of the left precentral gyrus (right-foot motor area), bilateral medial frontal regions (supplementary motor area), and the dysplastic gyrus. Hemodynamic response modeling to foot jerks revealed the hemodynamic response peaked earlier in the dysplastic cortex and SMA regions than in the foot area. Event-related fMRI in a patient with spontaneous and induced epileptic foot jerks revealed brain regions active during jerks. The results of this analysis allowed us to tailor subsequent intracerebral reco...Continue Reading

References

Jan 1, 1985·Epilepsia·M Hallett
Jan 1, 1985·Epilepsia·M HafezE Saied
Dec 24, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Louis LemieuxDavid R Fish
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·D MalonekA Grinvald
Jan 23, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karl J FristonR Turner
Oct 27, 1998·Human Brain Mapping·R L Buckner
Aug 17, 1999·Nature Neuroscience·N K LogothetisJ Pauls
Dec 20, 2003·NeuroImage·John S ArcherGraeme D Jackson
Jan 1, 1997·Human Brain Mapping·O JosephsKarl J Friston

Related Concepts

Functional Cerebral Localization
Insula of Reil
Electroencephalogram
Epilepsy, Myoclonic, Infantile
Potentials, Event-Related
Foot
Ambidexterity
Magnetization Transfer Contrast Imaging
Motor Cortex
Etat Marbre

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