Event-Related Potentials Allow for Optotype-Based Objective Acuity Estimation

Investigative Ophthalmology & Visual Science
Sven P HeinrichMichael Bach

Abstract

The event-related potential P300 has been proposed for objective acuity estimation. In contrast to the acuity VEP, which relies on grating or checkerboard stimuli, the P300 can be recorded to small stimulus differences, making it suitable to use optotype stimuli. This may result in a better agreement with subjective measures of acuity than that found with VEP-based estimates. We tested the feasibility of using Landolt C optotypes with a P300 acuity paradigm and assessed the relationship between subjective and objective acuity estimates for both optotype and grating stimuli. Dioptric blur (+1, +2, and +4 diopters) was used to degrade vision. Separate oddball sequences with Landolt Cs and with gratings, respectively, were used to record the P300. Thresholds were estimated by fitting a sigmoid curve to P300 amplitudes as a function of Landolt C size or grating coarseness, respectively. Psychophysical thresholds were also obtained for both stimulus types. There was a sizable discrepancy in psychophysical acuity estimates between Landolt C and grating stimuli, probably due to spurious resolution with gratings. With both stimulus types, reliable P300 acuity estimates were obtained. These reflected the psychophysical discrepancy. Conv...Continue Reading

Citations

May 16, 2015·Documenta Ophthalmologica. Advances in Ophthalmology·David J MarhöferSven P Heinrich
Aug 16, 2019·Documenta Ophthalmologica. Advances in Ophthalmology·William H Ridder
Sep 7, 2019·Documenta Ophthalmologica. Advances in Ophthalmology·Sven P Heinrich, Isabell Strübin
Nov 15, 2017·Documenta Ophthalmologica. Advances in Ophthalmology·Marvin L Beusterien, Sven P Heinrich
May 18, 2018·I-Perception·Hans StrasburgerSven P Heinrich
Nov 20, 2016·Documenta Ophthalmologica. Advances in Ophthalmology·Sven P HeinrichMichael Bach
Aug 18, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sven P HeinrichMichael Bach

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