PMID: 4894686Apr 1, 1969Paper

Events occurring during the replication of bacteriophage T4 DNA

Proceedings of the National Academy of Sciences of the United States of America
P D Scotti

Abstract

Ten temperature-sensitive mutants of T4D have been examined to find the times in the lytic cycle at which a shift to a restrictive temperature no longer exerts a lethal effect. Nine of these mutants play a role in phage DNA synthesis. The results of these experiments suggest that the products of three of the genes tested-genes 42, 44, and 45-have control or complexing functions in addition to any enzymatic ones. The data also indicate that the products of genes 30 and 41 may act cooperatively. The properties of mutants of gene 43 (DNA polymerase) and gene 56 (dCTP-dUTPase) suggest that the production of a certain length of concatameric DNA is necessary before viable phage can be produced.

References

Oct 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·H R Warner, J E Barnes
Jul 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·M Oishi
May 14, 1968·Journal of Molecular Biology·R Werner
Oct 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·A De WaardI R Lehman
Aug 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·G C Fareed, C C Richardson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.