Everolimus- and zotarolimus-eluting stents for bare metal stent in-stent restenosis treatment: a prospective study

Journal of Interventional Cardiology
Konstantinos ToutouzasChristodoulos Stefanadis

Abstract

Treatment of in-stent restenosis (ISR) is a challenging clinical problem. Recent studies have verified the safety and efficacy of first-generation DES for the treatment of ISR. The safety and effectiveness of new-generation drug-eluting stents (nDES) for ISR has not been previously investigated. The aim of the present study was to prospectively evaluate the clinical outcomes after treatment with nDES implantation in patients with bare metal stent (BMS) ISR. Consecutive patients with ISR after BMS implantation were included. Primary end-point was a major adverse cardiac event (MACE), defined as death, myocardial infarction (MI), or target vessel revascularization (TVR). The incidence of stent thrombosis was also evaluated. A total of 46 consecutive patients were enrolled for the treatment of ISR, 23 patients from ZES and 23 from EES group. There were two (8.7%) cases of TVR in ZES cohort due to proliferative ISR at 6 and 7 months after DES implantation, and none in EES. One (4.3%) patient underwent percutaneous coronary intervention and the other (4.3%) was treated surgically. Neither acute nor subacute thrombosis was observed during the 13.3+/-6.3 months follow-up period. In all other patients, stress test was negative for isch...Continue Reading

References

Jun 12, 1997·The New England Journal of Medicine·P S TeirsteinP Tripuraneni
Feb 15, 2001·The New England Journal of Medicine·M B LeonR E Kuntz
Jan 15, 2002·Journal of the American College of Cardiology·Harry C LoweLevon M Khachigian
Jun 7, 2002·The New England Journal of Medicine·Marie-Claude MoriceUNKNOWN RAVEL Study Group. Randomized Study with the Sirolimus-Coated Bx Velocity Balloon-Expandable Stent in the Treatment of Patie
Jul 3, 2002·European Heart Journal·C di Mario, K Toutouzas
Jan 22, 2003·Journal of the American College of Cardiology·Muzaffer DegertekinPatrick W Serruys
Mar 19, 2003·Zeitschrift für Kardiologie·Konstantinos ToutouzasAntonio Colombo
Jan 16, 2004·The New England Journal of Medicine·Gregg W StoneUNKNOWN TAXUS-IV Investigators
Apr 14, 2004·Circulation·Allen JeremiasJoseph P Carrozza
Jun 30, 2004·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Francesco SaiaPatrick W Serruys
Jan 13, 2005·JAMA : the Journal of the American Medical Association·Adnan KastratiUNKNOWN ISAR-DESIRE Study Investigators
Mar 16, 2005·Journal of the American College of Cardiology·Raúl MorenoCarlos Macaya
Jul 8, 2005·Coronary Artery Disease·Jorge A BelardiLiliana Grinfeld
Aug 18, 2005·The New England Journal of Medicine·Alban DibraUNKNOWN ISAR-DIABETES Study Investigators
Sep 15, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Philippe CommeauJean B Siméoni
Mar 15, 2006·JAMA : the Journal of the American Medical Association·Gregg W StoneUNKNOWN TAXUS V ISR Investigators
Mar 15, 2006·JAMA : the Journal of the American Medical Association·David R HolmesUNKNOWN SISR Investigators
Apr 18, 2006·The American Journal of Cardiology·Flavio AiroldiAntonio Colombo
Jun 7, 2006·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Andrew J CarterRenu Virmani
Jul 4, 2006·Journal of the American College of Cardiology·Michael JonerRenu Virmani
Jul 25, 2006·The American Journal of Cardiology·Duk-Woo ParkSeung-Jung Park
Oct 6, 2006·Journal of Interventional Cardiology·David E Kandzari, Martin B Leon
Dec 19, 2006·Journal of the American College of Cardiology·David E KandzariUNKNOWN ENDEAVOR III Investigators
Dec 26, 2006·Expert Review of Medical Devices·Marcel A M Beijk, Jan J Piek
Feb 14, 2007·The New England Journal of Medicine·Laura MauriDonald E Cutlip
Feb 14, 2007·The New England Journal of Medicine·Bo LagerqvistUNKNOWN SCAAR Study Group
Feb 14, 2007·The New England Journal of Medicine·Adnan KastratiAlbert Schömig
Feb 14, 2007·The New England Journal of Medicine·Gregg W StoneMartin B Leon
Feb 14, 2007·The New England Journal of Medicine·Christian SpauldingPatrick W Serruys
May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
Jul 4, 2007·Herz·Gaku NakazawaRenu Virmani
Nov 21, 2007·The American Journal of Cardiology·Gaku NakazawaRenu Virmani
Nov 21, 2007·The American Journal of Cardiology·Anthony GershlickUNKNOWN ENDEAVOR Investigators
Nov 21, 2007·The American Journal of Cardiology·Ian T MeredithUNKNOWN ENDEAVOR I Investigators
Nov 21, 2007·The American Journal of Cardiology·Ajay K JainUNKNOWN E-Five Investigators

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Citations

Jul 7, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Michael S LeeKeith D Dawkins
Jun 2, 2011·The American Journal of the Medical Sciences·Andreas SynetosChristodoulos Stefanadis

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