Everolimus Versus Temsirolimus in Metastatic Renal Cell Carcinoma After Progression With Previous Systemic Therapies

Clinical Genitourinary Cancer
Shiven B PatelNeeraj Agarwal

Abstract

Everolimus is an approved agent for use after disease progression with vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs) in patients with metastatic renal cell carcinoma. With recently published trials showing efficacy of nivolumab and cabozantinib in the second-line therapy setting, the use of everolimus will likely move to the third- or fourth-line therapy setting. Temsirolimus has occasionally been used instead of everolimus for many reasons, including financial considerations, assurance of patient compliance given its intravenous administration, its toxicity profile, patient performance status, and patient or physician preference. However, efficacy of everolimus and temsirolimus in this setting have not been compared in a randomized trial. The results from retrospective studies have been inconsistent. We identified patients treated with a first-line VEGFR-TKI for metastatic renal cell carcinoma and then treated with either everolimus or temsirolimus on progression from the databases of 2 large academic cancer centers. Progression-free survival (PFS) and overall survival (OS) were assessed from the initiation of second-line treatment using the Kaplan-Meier method. A total of 90 patients rece...Continue Reading

References

Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael B AtkinsMatthew L Sherman
Jun 1, 2007·The New England Journal of Medicine·Gary HudesUNKNOWN Global ARCC Trial
Mar 12, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne O'DonnellIan Judson
Jul 14, 2010·Annals of Surgery·Hilaire J ThompsonEllen J Mackenzie
Dec 15, 2010·The Oncologist·Heinz-Josef KlümpenJan H M Schellens
Oct 16, 2012·Clinical Genitourinary Cancer·Nicholas J VogelzangThomas E Hutson
Dec 4, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E HutsonRobert J Motzer
Feb 4, 2014·Clinical Genitourinary Cancer·Nimira AlimohamedDaniel Y C Heng
Mar 29, 2014·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Roberto IacovelliGiuseppe Procopio
Sep 26, 2015·The New England Journal of Medicine·Robert J MotzerUNKNOWN CheckMate 025 Investigators
Sep 26, 2015·The New England Journal of Medicine·Toni K ChoueiriUNKNOWN METEOR Investigators

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Citations

Jun 25, 2016·International Journal of Molecular Sciences·Moto Kajiwara, Satohiro Masuda
Aug 11, 2020·Frontiers in Cell and Developmental Biology·Christopher Montemagno, Gilles Pagès

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