journal cover

Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer's disease

Neurobiology of Disease

Jan 14, 2020

Divna LazicMilka Perovic

Abstract

Food restriction has been widely associated with beneficial effects on brain aging and age-related neurodegenerative diseases such as Alzheimer's disease. However, previous studies on the effects of food restriction on aging- or pathology-related cognitive decline are controversial, emp...read more

Mentioned in this Paper

Laboratory mice
Pathology
Neurodegenerative Disorders
Protein Expression
Plants, Transgenic
SLC1A2
Alzheimer's Disease
Neuronal Plasticity
Inflammation
Food
9
1
1
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Organelles in Neurodegeneration

Neurodegeneration is the progressive loss of neural structures and functions, including neuronal death. This feed focuses on dynamics of neuronal organelles in neurodegenerative diseases.

Parkinson's Disease: Animal Models

Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on animal models used for Parkinson's disease research.

Gfral Neurons Reduce Food Intake

GFRAL is a receptor for growth differentiation factor 15 (GDF15). These proteins play a role in regulating inflammatory pathways, as well as cell repair, apoptosis, cell growth, and body-weight regulation. Here is the latest research on the role of GFRAL-expressing neurons in reducing food intake.

Inflammation & Obesity

Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state. Discover the latest research on inflammation and obesity here.

Neurotoxicity, Inflammation & Neuroprotection

The end result of the inflammatory process, neurotoxicity and/or neuroprotection, is a function of the fine balance between the two cellular systems, i.e., of the complex signaling relationships between anti-inflammatory neuroprotective factors (neurotrophins and other chemical mediators) and proinflammatory neurotoxic factors (tnf, free radicals, certain cytokines, etc). Here are the latest discoveries pertaining to neurotoxicity, inflammation and neuroprotection.

Functional Connectivity Networks

Functional connectivity networks represent specific patterns of synchronous activity and differ between healthy subjects, stages of consciousness and across disease. Discover the latest research on functional connectivity networks here.

Alzheimer's Disease: Genes&Microglia

Genes and microglia are associated with the risk of developing and the progression of conditions such as Alzheimer's Disease (AD). Here are the latest discoveries pertaining to this disease.

Microglia: Health and Disease

Microglia are the resident macrophages of the central nervous system. Microglia-derived inflammatory neurotoxins play a principal role in the pathogenesis of several neurodegenerative disorders. Here is the latest research on the role of microglia in health and disease.

Innate Immunity: Neurodegeneration

The innate immune system is a first line of defense against infection. Pathological states can occur if there is over activation of the innate immune system, particularly in the. The excessive activation of these cells can lead to inflammation and neurodegenerative diseases. Here is the latest research on innate immunity and neurodegeneration.

Inflammation during Aging

Slow, low-grade inflammation occurs during aging, however the mechanisms that are involved are still largely unclear. Pro-inflammatory biomarkers have been associated with cognitive decline and neurodegeneration. Here is the latest research on inflammation during aging.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Dementia & Neurodegenerative Diseases

This feed focuses on the impact of insulin resistance, caloric restriction, cytokine singling, and metabolism on dementia and neurodegenerative diseases. Here is the latest research in this domain.

Misfolded Proteins: ND

Protein misfolding is the primary cause of several neurodegenerative disease, including Alzheimer’s and Parkinson’s disease. Here is the latest research.

Gut Microbiome & the Brain

Microbes in the gut communicate with the central nervous system (CNS) via at least three parallel and interacting channels including endocrine, nervous, and immune signaling. Here is the latest research on the brain-gut-microbiome axis.

Cell Aging

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Hippocampus & Feeding

Human and animal data suggest that the hippocampus plays many roles in regulating food intake. Discover the latest research on hippocampus and feeding here.

Microglia & Spinal Somatosensory Circuits

Microglia are found throughout the brain and spinal cord and are the resident macrophages of the CNS. There have been investigations into the involvement of microglia in somatosensory sensory circuits within the spinal cord and associated diseases. Here is the latest research on microglia and spinal somatosensory circuits.

Alzheimer's Disease: Abeta

Alzheimer's disease (AD) is a chronic neurodegenerative disease associated with accumulation of amyloid plaques, which are comprised of amyloid beta. Here is the latest research in this field.

Sonic Hedgehog Signaling

The Sonic Hedgehog signaling pathway regulates developmental processes including cell patterning and differentiation and plays a role in tissue repair and regeneration. Here is the latest research on this complex signal transduction pathway.

Neurotransmitters in Feeding

Serotonin and dopamine are neurotransmitters involved in feeding and eating disorders. Here are the latest discoveries pertaining to neurotransmitters in feeding.

Neuroinflammation

Neuroinflammation is a defensive response, characterized by the activation of proinflammatory molecules including microglia and astrocytes. The response has been implicated in brain injuries, acute and chronic neurological and neurodegenerative disorders such as Alzheimer’s disease. Here is the latest research on neuroinflammation.

Neuronal Plasticity

Neuronal plasticity is the brain’s ability to change its structure and function in response to internal or external factors. Here is the latest research on mechanisms that influence this process.

Microglia And CNS Diseases

Microglia are resident macrophages of the CNS. They play a role in scavenging the CNS for plaques, phagocytosis, and extracellular signaling. Here is the latest research on their role in CNS diseases.

Neurodegeneration: Microglia & TDP-43

TDP43 is is implicated in several neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis and frontotemporal lobe dementia. It has also been shown to regulate microglial phagocytosis. Here is the latest research on the role of TDP43 and microglia in neurodegeneration.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Neural Circuits Regulating Feeding

Neurons within the central nervous system receive signals that regulate feeding and metabolism. Here are the latest discoveries pertaining to neural circuits in regulating feeding.

Astrocytes & Huntington’s Disease

Astrocytes are abundant within the central nervous system and their dysfunction has been thought to be an important contributor to some neurodegenerative diseases, in particular Huntington’s disease. Damage to these cells may make neurons more susceptible to degeneration. Here is the latest research on astrocytes and Huntington’s disease.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Alzheimer's Disease: Animal models

Alzheimer's disease is a chronic neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Blood Brain Barrier & Cytokines

Cytokines can affect the central nervous system through crossing the blood brain barrier and entering the CSF and interstitial fluid spaces. Some cytokines are able to cross through transport systems and can affect tissues within the CNS, whereas others are unable to cross. Here is the latest research on the blood brain barrier and cytokines.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Related Papers

© 2020 Meta ULC. All rights reserved

Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer's disease

Neurobiology of Disease

Jan 14, 2020

Divna LazicMilka Perovic

PMID: 31931140

DOI: 10.1016/j.nbd.2020.104745

Abstract

Food restriction has been widely associated with beneficial effects on brain aging and age-related neurodegenerative diseases such as Alzheimer's disease. However, previous studies on the effects of food restriction on aging- or pathology-related cognitive decline are controversial, emp...read more

Mentioned in this Paper

Laboratory mice
Pathology
Neurodegenerative Disorders
Protein Expression
Plants, Transgenic
SLC1A2
Alzheimer's Disease
Neuronal Plasticity
Inflammation
Food
9
1
1

Similar Papers Found In These Feeds

Organelles in Neurodegeneration

Neurodegeneration is the progressive loss of neural structures and functions, including neuronal death. This feed focuses on dynamics of neuronal organelles in neurodegenerative diseases.

Parkinson's Disease: Animal Models

Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on animal models used for Parkinson's disease research.

Related Papers

Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
/papers/every-other-day-feeding-exacerbates-inflammation/31931140