Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer's disease and FDG-PET findings

Scientific Reports
Jung-Lung HsuChyi-Huey Bai

Abstract

We applied the Everyday Cognition (ECog) scale in normal aging adults and patients with Alzheimer's disease (AD) to investigate associations between neuropsychological tests and neuroimaging markers. A total of 160 normal aging adults and 40 patients with the early stage of probable AD were included. Neuropsychological performance was assessed using the Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-NAB). 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans were used to measure AD-related hypometabolism. Nonparametric Spearman correlation analysis was used to study associations between ECog and z-transformed total CERAD-NAB scores in both groups. The results revealed a significant correlation between total ECog and CERAD-NAB scores (rho = -0.28, p < 0.01), and category verbal fluency test with the executive domain of the ECog scale (rho = -0.20, p < 0.01). The CERAD-NAB scores were also significantly correlated with AD-related hypometabolism (rho = -0.49, p < 0.01). The memory domain of the ECog scale was significantly correlated with FDG uptake in the angular gyrus and posterior cingulum gyrus (rho = -0.41 and -0.46, P < 0.01). In conclusion, both total an...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Oct 1, 1973·The British Journal of Psychiatry : the Journal of Mental Science·B Isaacs, A T Kennie
Aug 1, 1971·Scientific American·R C Atkinson, R M Shiffrin
Nov 1, 1984·The American Journal of Psychiatry·W G RosenK L Davis
Jun 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·C P HughesR L Martin
Aug 1, 1994·American Journal of Public Health·T P SuurmeijerW J van den Heuvel
Oct 6, 1997·Neurology·K A Welsh-Bohmer, R C Mohs
Jul 16, 2003·Acta Neurologica Scandinavica·M Karrasch, M Laine
Jul 2, 2008·Neuropsychology·Sarah Tomaszewski FariasCharles Decarli
Jun 10, 2009·Journal of the American Geriatrics Society·Sujuan GaoHugh C Hendrie
Jan 30, 2010·Journal of Alzheimer's Disease : JAD·Eric D VidoniJeffrey M Burns
May 28, 2010·Alzheimer Disease and Associated Disorders·Heidi C RossettiLaura H Lacritz
Aug 5, 2010·Journal of the International Neuropsychological Society : JINS·Michael M EhrenspergerAndreas U Monsch
Sep 9, 2010·Brain : a Journal of Neurology·James E GalvinJohn C Morris
Jan 5, 2011·Acta Neurologica Scandinavica·M SotaniemiT Hänninen
Jun 8, 2011·Archives of General Psychiatry·Patrick J BrownUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 23, 2011·Dementia and Geriatric Cognitive Disorders·Gad A MarshallKeith A Johnson
Feb 22, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Anna CaroliUNKNOWN EADC-PET Consortium, NEST-DD, and Alzheimer's Disease Neuroimaging Initiative
Feb 2, 2013·Journal of the International Neuropsychological Society : JINS·Sarah Tomaszewski FariasDan Mungas
Feb 8, 2014·The Clinical Neuropsychologist·Lauren A RogSarah Tomaszewski Farias
Aug 27, 2014·Journal of the International Neuropsychological Society : JINS·Emily C EdmondsUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jan 16, 2015·Alzheimer Disease and Associated Disorders·Lovingly Q ParkSarah T Farias
Jul 16, 2016·Applied Neuropsychology. Adult·Shu-Fen HuangChwen-Yng Su

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SAS
PMOD
ECog

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