Everyday Function in Alzheimer's and Parkinson's Patients with Mild Cognitive Impairment.

Journal of Alzheimer's Disease : JAD
Sara BeckerAlzheimer’s Disease Neuroimaging Initiative

Abstract

Instrumental activities of daily living (IADL) impairment can begin in mild cognitive impairment (MCI), and is the core criteria for diagnosing dementia in both Alzheimer's (AD) and Parkinson's (PD) diseases. The Functional Activities Questionnaire (FAQ) has high discriminative power for dementia and MCI in older age populations, but is influenced by demographic factors. It is currently unclear whether the FAQ is suitable for assessing cognitive-associated IADL in non-demented PD patients, as motor disorders may affect ratings. To compare IADL profiles in MCI patients with PD (PD-MCI) and AD (AD-MCI) and to verify the discriminative ability of the FAQ for MCI in patients with (PD-MCI) and without (AD-MCI) additional motor impairment. Data of 42 patients each of PD-MCI, AD-MCI, PD cognitively normal (PD-CN), and healthy controls (HC), matched according to age, gender, education, and global cognitive impairment were analyzed. ANCOVA and binary regressions were used to examine the relationship between the FAQ scores and groups. FAQ cut-offs for PD-MCI (versus PD-NC) and AD-MCI (versus HC) were separately identified using receiver operating characteristic analyses. FAQ total score did not differentiate between MCI groups. PD-MCI su...Continue Reading

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Citations

Jun 11, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sara BeckerInga Liepelt-Scarfone
Jun 30, 2021·Journal of Neuroscience Research·Hannah D LoennekerHans-Christoph Nuerk

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