Everyone loves an underdog: metabolic engineering of the xylose oxidative pathway in recombinant microorganisms

Applied Microbiology and Biotechnology
Kris Niño G ValdehuesaWook-Jin Chung

Abstract

The D-xylose oxidative pathway (XOP) has recently been employed in several recombinant microorganisms for growth or for the production of several valuable compounds. The XOP is initiated by D-xylose oxidation to D-xylonolactone, which is then hydrolyzed into D-xylonic acid. D-Xylonic acid is then dehydrated to form 2-keto-3-deoxy-D-xylonic acid, which may be further dehydrated then oxidized into α-ketoglutarate or undergo aldol cleavage to form pyruvate and glycolaldehyde. This review introduces a brief discussion about XOP and its discovery in bacteria and archaea, such as Caulobacter crescentus and Haloferax volcanii. Furthermore, the current advances in the metabolic engineering of recombinant strains employing the XOP are discussed. This includes utilization of XOP for the production of diols, triols, and short-chain organic acids in Escherichia coli, Saccharomyces cerevisiae, and Corynebacterium glutamicum. Improving the D-xylose uptake, growth yields, and product titer through several metabolic engineering techniques bring some of these recombinant strains close to industrial viability. However, more developments are still needed to optimize the XOP pathway in the host strains, particularly in the minimization of by-produ...Continue Reading

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Citations

Jun 27, 2019·Biotechnology and Bioengineering·Tobias PlochStephan Noack
Feb 29, 2020·Nature Communications·Lu ShenBettina Siebers
Dec 17, 2018·Journal of Industrial Microbiology & Biotechnology·Rhudith B CabulongWook-Jin Chung
Jan 5, 2020·Applied Microbiology and Biotechnology·Angelo B BañaresWook-Jin Chung
Feb 11, 2021·Critical Reviews in Biotechnology·Angelo B BañaresWook-Jin Chung
Feb 3, 2021·Bioprocess and Biosystems Engineering·Rhudith B CabulongWook-Jin Chung
Jul 3, 2021·Microorganisms·Christiane Ribeiro Janner HerreraFernando Araripe Gonçalves Torres
Jul 4, 2021·Applied Microbiology and Biotechnology·Angelo B BañaresWook-Jin Chung
Sep 10, 2021·Applied Microbiology and Biotechnology·Ana Karen MalánSilvia Batista

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