Evidence against a role for inducible nitric oxide synthase in the hyperdynamic circulation of portal-hypertensive rats

Gastroenterology
M FernándezJ Rodés

Abstract

Excessive nitric oxide biosynthesis caused by expression of inducible NO synthase has been implicated in the hyperdynamic circulation of portal hypertension. The aim of the study was to investigate whether inducible NO synthase is expressed in portal hypertension an accounts for the hyperdynamic circulation. In study 1, NO synthase activities were measured by the conversion of L-arginine to citrulline in tissues from portal-hypertensive, cirrhotic, and sham-operated rats and from normal rats pretreated with endotoxin and after long-term administration of dexamethasone, which inhibits the expression of inducible NO synthase. In study 2, systemic and splanchnic hemodynamics (radiolabeled microspheres) and gastric blood flow (hydrogen gas clearance and reflectance spectrophotometry) were measured in portal-hypertensive rats after long-term administration of dexamethasone (0.25 mg.kg-1.day-1) or vehicle. In study 1, constitutive and inducible NO synthase activities in portal-hypertensive or cirrhotic rats were similar to those observed in sham-operated rats. The significant increase in the inducible activity observed after endotoxin injection was prevented when rats received long-term treatment with dexamethasone. In study 2, cardi...Continue Reading

References

Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Y LeeR J Groszmann
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W RadomskiS Moncada
Mar 30, 1991·Lancet·P Vallance, S Moncada
Jun 1, 1991·British Journal of Pharmacology·R T MathieG Burnstock
Jan 1, 1991·Journal of Hepatology·F BendtsenJ H Henriksen
Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A B LumsdenM H Kutner
Jan 1, 1980·Scandinavian Journal of Gastroenterology·J H HenriksenH Ring-Larsen
Nov 1, 1993·British Journal of Pharmacology·N K Boughton-SmithS Moncada
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D SalveminiP Needleman
Nov 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C GuarnerS Moncada
Aug 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M FernándezJ Rodés
Sep 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M CasadevallB J Whittle
Jun 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G Garcia-TsaoA B West

❮ Previous
Next ❯

Citations

Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M C HouJ V Sitzmann
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M OhtaI J Sarfeh
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Fernandez, H L Bonkovsky
Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J HellerD Lebrec
Jan 4, 2001·European Journal of Pharmacology·A NahavandiM R Abdolhoseini
Aug 29, 2003·The Journal of Surgical Research·E K BhimaniR T Mathie
Mar 23, 2000·Journal of Hepatology·J Bosch, J C García-Pagán
Feb 28, 2002·Journal of Hepatology·Victoria AndreuJoan Rodés
Jul 1, 1996·Journal of Hepatology·S KanwarS S Lee
Aug 29, 1998·Journal of Hepatology·C M Fernández-RodriguezF Cuttitta
Mar 15, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·V BarónP Muriel
May 20, 1998·Nutrition·B Alexander
Jun 26, 2001·Liver·R Farzaneh-Far, K Moore
Jan 13, 2001·British Journal of Pharmacology·S CalatayudJ V Esplugues
Jan 23, 1999·Journal of Autonomic Pharmacology·J McDaidJ R Docherty
Sep 5, 2002·Clinical and Experimental Pharmacology & Physiology·Ali R ManiAhmad R Dehpour
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Reiner Wiest, Roberto J Groszmann
Jan 1, 1997·Journal of Clinical Gastroenterology·J G Ferraz, J L Wallace
Mar 27, 2003·Inflammatory Bowel Diseases·Zvi AckermanDaniel Rachmilewitz
Mar 4, 2005·Clinical and Experimental Pharmacology & Physiology·M A ErarioM L Tomaro
Nov 23, 2011·Critical Care : the Official Journal of the Critical Care Forum·Len VerbekeWim Laleman
Mar 15, 2015·Journal of the Chinese Medical Association : JCMA·Hsin-Ling Ho, Hui-Chun Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.