PMID: 8941510Nov 1, 1996Paper

Evidence against an increase in capillary permeability in subjects exposed to high altitude

Journal of Applied Physiology
G R KlegerP E Ballmer

Abstract

A potential pathogenetic cofactor for the development of acute mountain sickness and high-altitude pulmonary edema is an increase in capillary permeability, which could occur as a result of an inflammatory reaction and/or free radical-mediated injury to the lung. We measured the systemic albumin escape by intravenously injecting 5 muCi of 125I-labeled albumin and the plasma concentrations of cytokines, F2-isoprostanes (products of lipid peroxidation), and acute-phase proteins in 24 subjects exposed to 4,559 m. Ten subjects developed acute mountain sickness, and four subjects developed high-altitude pulmonary edema. The transcapillary escape rate of albumin was 6.9 +/- 2.0%/h (SD) at low (550 m) and 6.3 +/- 1.9%/h at high (4,559 m) altitude (P = 0.23; n = 24). The subjects with high-altitude pulmonary edema had a modest but insignificant increase in the transcapillary escape rate of albumin (4.6 +/- 1.9%/h at low vs. 5.7 +/- 1.9%/h at high altitude; P = 0.42; n = 4). Plasma concentrations of fibrinogen, alpha 1-acid glycoprotein, C-reactive protein, and interleukin-6 were unchanged in the early phases and significantly increased by the end of the observation period in the subjects with high-altitude pulmonary edema, whereas tumo...Continue Reading

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Citations

Feb 13, 2001·Journal of Applied Physiology·R ImoberdorfP E Ballmer
May 15, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·E D MichelakisS L Archer
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P MøllerN V Olsen
Sep 21, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xueqin Ding, Paul A Murray
Jun 25, 2005·Journal of Applied Physiology·Christopher J GoreCaroline M Burge
Mar 10, 2015·Journal of Applied Physiology·C SiebenmannC Lundby
Sep 25, 2020·High Altitude Medicine & Biology·Marc Moritz BergerPeter Bärtsch
Apr 16, 1998·Journal of Applied Physiology·T C CarpenterA G Durmowicz
Jan 30, 1999·Medicine and Science in Sports and Exercise·P Bärtsch
Oct 27, 2004·Journal of Applied Physiology·Jack A LoeppkyRobert C Roach
Aug 28, 2004·Clinical Science·Damian M BaileyMohammed Ghatei
Feb 28, 2007·Anesthesiology·Xueqin Ding, Paul A Murray
Jul 10, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ciprian DospinescuStuart F Cruickshank
Mar 12, 2015·High Altitude Medicine & Biology·Tan YueLi Min
Jun 28, 2014·High Altitude Medicine & Biology·Gabriel WillmannPeter Bärtsch
Jun 3, 2017·Journal of Applied Physiology·Christoph SiebenmannCarsten Lundby
Dec 10, 2002·Medicine and Science in Sports and Exercise·Christoph DehnertPeter Bärtsch
Apr 27, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alexander ChoukèrManfred Thiel
Dec 20, 2014·Journal of Applied Physiology·Sandro AltamuraHeimo Mairbäurl
Jun 20, 2015·Journal of Applied Physiology·Marc Moritz BergerPeter Bärtsch
Dec 19, 2015·High Altitude Medicine & Biology·Christopher John BoosAdrian J Mellor
Aug 10, 2001·Drug Metabolism Reviews·Z H Israili, P G Dayton
Dec 10, 2002·Medicine and Science in Sports and Exercise·Bente Klarlund Pedersen, Adam Steensberg
Apr 13, 2021·Frontiers in Physiology·Andrés Pedreros-LobosFernando A Moraga
Jun 13, 2003·Lancet·Buddha Basnyat, David R Murdoch

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