PMID: 3753698Jan 1, 1986Paper

Evidence against the role of calcium deficiency in genetic hypertension

Hypertension
K LauD Zikos

Abstract

Epidemiological studies suggest an association between reduced calcium uptake and hypertension, while clinical trials and rat experiments indicate a small but significant hypotensive effect with oral calcium supplements. These data imply that calcium deficiency has a role in genetic hypertension. We reasoned that if the hypothesis is correct, the hypertension should be aggravated by further reducing calcium balance but attenuated by augmenting calcium balance. We tested this hypothesis by evaluating the blood pressure response in spontaneously hypertensive rats (SHR) as calcium balance was decreased by dietary restriction of calcium or increased by supplementation with magnesium or 1 alpha, 25-dihydroxycholecalciferol (calcitriol). A low calcium diet within the physiological range did not accentuate the hypertension in SHR during the 11 weeks of treatment, even though calcium balance was reduced by half. Similar results were obtained with dietary calcium restriction in parathyroidectomized SHR, which excludes any offsetting effects of changes in parathyroid hormone levels. Conversely, 7 weeks of a high magnesium diet, which increased calcium balance without reducing PO4 balance, did not correct the hypertension of SHR. Similarl...Continue Reading

References

Dec 1, 1979·Metabolism: Clinical and Experimental·S Ayachi
Oct 1, 1978·The American Journal of Physiology·J T CroftonD Tarnowski
Sep 1, 1977·The Journal of Clinical Investigation·R RizzoliJ P Bonjour
Dec 1, 1974·Journal of Applied Physiology·Y ItokawaM Fujiwara
Feb 1, 1968·The American Journal of Physiology·I Clark
Aug 1, 1983·Clinical Science·P StrazzulloM Mancini
Mar 4, 1983·JAMA : the Journal of the American Medical Association·J M BelizanR Sibrian
Mar 1, 1984·The American Journal of Physiology·K LauB Eby
Apr 1, 1984·The Journal of Clinical Investigation·H P SchedlH D Wilson
Jun 29, 1984·Science·D A McCarronJ L Stanton
Jul 22, 1982·The New England Journal of Medicine·D A McCarron
Sep 1, 1982·The American Journal of Physiology·G L Wright, G O Rankin
May 1, 1981·Hypertension·D A McCarronS Krutzik
Nov 1, 1981·Japanese Circulation Journal·R SchleifferA Gairard
Oct 1, 1981·The American Journal of Physiology·M A Toraason, G L Wright

❮ Previous
Next ❯

Citations

Jan 1, 1989·Fundamental & Clinical Pharmacology·S LaurentH Schmitt
Apr 1, 1987·Pflügers Archiv : European journal of physiology·R J BindelsC H van Os
Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·E I MangiaruaW D McCumbee
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·G H EvansC F Babbs
Feb 1, 1989·Kidney International·D A McCarron
Oct 1, 1986·Kidney International·U GafterK Lau
Jan 30, 2003·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Aaron W GrossmanWilliam T Greenough
Oct 3, 1999·Physiological Reviews·J Zicha, J Kunes
Jun 1, 1987·The American Journal of Physiology·E W YoungP Komanicky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical and Experimental Hypertension. Part A, Theory and Practice
E I BloomquistV Karr-Dullien
Clinical and Experimental Hypertension. Part A, Theory and Practice
P ChampérouxM Safar
© 2021 Meta ULC. All rights reserved