Evidence-based approach to the management of sporadic medullary thyroid carcinoma

World Journal of Surgery
Jeffrey F Moley, Elizabeth A Fialkowski


Medullary thyroid carcinoma (MTC) is a rare malignancy of the thyroid C cells. It occurs in hereditary (25% of cases) and sporadic (75%) forms. Sporadic MTCs frequently metastasize to cervical lymph nodes. Thorough surgical extirpation of the primary tumor and nodal metastases by compartment-oriented resection has been the mainstay of treatment (level IV evidence). Surgical resection of residual and recurrent disease is effective in reducing calcitonin levels and controlling complications of central neck disease (level IV evidence). Radioactive iodine, external beam radiation therapy, and conventional chemotherapy have not been effective. Newer systemic treatments, with agents that target abnormal RET proteins hold promise and are being tested in clinical trials for patients with metastatic disease.


Jul 1, 1983·The Journal of Clinical Endocrinology and Metabolism·M F SaadN A Samaan
Apr 1, 1995·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H J BuhrC Herfarth
Oct 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F OrlandiA Angeli
Jan 1, 1996·World Journal of Surgery·R UdelsmanP Ladenson
Aug 1, 1996·Thyroid : Official Journal of the American Thyroid Association·J BrierleyT Panzarella
Jun 1, 1997·Annals of Surgery·J F MoleyM K DeBenedetti
Jun 20, 1998·World Journal of Surgery·J F HenryC De Micco
Nov 24, 1999·Annals of Surgery·J B FlemingD B Evans
Oct 19, 2000·World Journal of Surgery·J L PeixF Mancini
Nov 2, 2001·The American Journal of Surgical Pathology·K KasererB Niederle
Dec 12, 2001·The Journal of Clinical Endocrinology and Metabolism·M L BrandiS J Marx
Aug 23, 2002·The British Journal of Surgery·H Dralle
May 21, 2003·Journal of Internal Medicine·M S Cohen, J F Moley
Nov 2, 2004·World Journal of Surgery·Jörg UkkatHenning Dralle
Jan 7, 2005·The Journal of Clinical Endocrinology and Metabolism·Andreas MachensHenning Dralle
Jan 27, 2005·The British Journal of Surgery·P TamagniniJ F Henry
Feb 19, 2005·Journal of Surgical Oncology·Frank J Quayle, Jeffrey F Moley
Jun 1, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A HamyJ-L Kraimps
Jun 2, 2005·British Journal of Cancer·A J Ryan, S R Wedge
Jun 22, 2005·Current Treatment Options in Oncology·Frank Jay Quayle, Jeffrey F Moley
Jan 25, 2006·Annals of Surgery·Stefan HeinrichPierre-Alain Clavien
Mar 15, 2006·Nuclear Medicine Communications·Murat Faik ErdoganNuri Kamel
Mar 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-François ChatalUNKNOWN French Endocrine Tumor Group

❮ Previous
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Mar 5, 2013·Langenbeck's Archives of Surgery·Henning DralleUNKNOWN German Societies of General and Visceral Surgery; Endocrinology; Nuclear Medicine; Pathology; Radiooncology; Oncological Hem
Nov 15, 2012·Endocrine Pathology·Boban M ErovicOzgur Mete
Jun 11, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Jan Zedenius
May 28, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association Guidelines Task ForceSamuel A Wells
May 15, 2010·Thyroid : Official Journal of the American Thyroid Association·Maria Pia RicciatoSalvatore Maria Corsello
Jul 3, 2008·Annals of Surgical Oncology·Maya D LeggettSteve R Martinez
Apr 22, 2011·Journal of Cancer·Marlon A GuerreroOrlo H Clark
Sep 20, 2012·European Journal of Endocrinology·Maria AlevizakiEleni Anastasiou
Dec 12, 2012·Case Reports in Endocrinology·Mehtab AhmadNoorin Zaidi
Jan 21, 2010·Familial Cancer·Friedhelm Raue, Karin Frank-Raue
Nov 11, 2009·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·H DralleA Machens
Oct 8, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Samira Basir ShabestariFarzaneh Agha-Hosseini
Sep 3, 2011·Journal of Visceral Surgery·S NoulletF Menegaux
Oct 20, 2009·The Surgical Clinics of North America·Tricia A Moo-YoungJeffrey F Moley
Sep 25, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Karin Frank-Raue, Friedhelm Raue
Jan 17, 2009·La Presse médicale·Christine Do Cao, Jean-Louis Wémeau
Dec 2, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Henning Dralle, Andreas Machens
Jul 8, 2008·Oral and Maxillofacial Surgery Clinics of North America·James I CohenUNKNOWN Associazione Medici Endocrinologi
Jan 8, 2008·Surgical Oncology Clinics of North America·Timothy A ManzonePrakash Seshadri
Jun 16, 2009·Journal of Internal Medicine·W van VeelenC J M Lips
Jul 22, 2010·Journal of Surgical Oncology·Steve R MartinezPhilip D Schneider
Mar 18, 2010·The British Journal of Surgery·M CherenkoJ F Henry
Oct 30, 2014·Journal of Surgical Oncology·Kathryn J Rowland, Jeffrey F Moley
May 23, 2015·The Journal of Laryngology and Otology·A BowenB Yap
Apr 2, 2010·Journal of Korean Medical Science·Yong Sang LeeCheong Soo Park
Jul 13, 2012·Journal of Korean Medical Science·Tae-Yon SungWoong Youn Chung
Dec 23, 2008·Advances in Anatomic Pathology·Jennifer L Hunt
Feb 16, 2011·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Ahmad Sukari HalimShah Jumaat Mohd Yussof
May 31, 2014·The Journal of Clinical Endocrinology and Metabolism·D VriensL F de Geus-Oei
Sep 1, 2009·Expert Review of Endocrinology & Metabolism·Cornelis Jm LipsJo Wm Höppener
Jul 14, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Alexander W SauterMelpomeni Fani

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