Evidence-based neonatal pharmacotherapy: postnatal corticosteroids

Clinics in Perinatology
Kristi L Watterberg

Abstract

Corticosteroids are used in the neonatal intensive care unit primarily to treat two conditions: bronchopulmonary dysplasia (BPD) and hypotension (cardiovascular insufficiency). Historically, high-dose dexamethasone was used for BPD, but its use was later associated with adverse neurodevelopmental outcomes and decreased substantially. Data from randomized controlled trials regarding efficacy and safety of lower-dose dexamethasone therapy are insufficient to recommend its use. Hydrocortisone may be an alternative to dexamethasone, but again data are insufficient to support use. Hydrocortisone therapy is increasingly used to treat hypotension in critically ill newborns; however, the outcomes of this therapy must be evaluated in randomized trials.

References

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Citations

Sep 6, 2014·PloS One·Jonathan L SlaughterSudarshan R Jadcherla
Feb 15, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·K KasatD Davidson
Feb 15, 2014·Clinics in Perinatology·Shadi N Malaeb, Barbara S Stonestreet
Oct 22, 2013·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·G SalasD Fariña
Jun 11, 2015·Acta Paediatrica·Outi M PeltoniemiUNKNOWN Neonatal Hydrocortisone Working Group
May 8, 2013·Acta Paediatrica·Etienne Fortin-PellerinAnnie Janvier
Apr 5, 2013·Acta Paediatrica·Mohamed Ben SaidJean-Charles Picaud
Oct 1, 2014·Pediatric Research·Lawrence C Ku, P Brian Smith
Jun 9, 2016·The American Journal of Tropical Medicine and Hygiene·Wit WichaiditPavani K Ram
Feb 22, 2018·Current Opinion in Pediatrics·Lannae Strueby, Bernard Thébaud
Mar 1, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Deepak Jain, Eduardo Bancalari

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