Evidence-based prevention and treatment of osteoporosis after spinal cord injury: a systematic review.

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Saeed Soleyman-JahiVafa Rahimi-Movaghar

Abstract

Spinal cord injury (SCI) results in accelerated bone mineral density (BMD) loss and disorganization of trabecular bone architecture. The mechanisms underlying post-SCI osteoporosis are complex and different from other types of osteoporosis. Findings of studies investigating efficacy of pharmacological or rehabilitative interventions in SCI-related osteoporosis are controversial. The aim of this study was to review the literature pertaining to prevention and evidence-based treatments of SCI-related osteoporosis. In this systematic review, MEDLINE, EMBASE, PubMed, and the Cochrane Library were used to identify papers from 1946 to December 31, 2015. The search strategy involved the following keywords: spinal cord injury, osteoporosis, and bone loss. Finally, 56 studies were included according to the inclusion criteria. Only 16 randomized controlled trials (involving 368 patients) were found. We found following evidences for effectiveness of bisphosphonates in prevention of BMD loss in acute SCI: very low-quality evidence for clodronate and etidronate, low-quality evidence for alendronate, and moderate-quality evidence for zoledronic acid. Low-quality evidence showed no effectiveness for tiludronate. In chronic SCI cases, we found ...Continue Reading

References

Apr 1, 1992·Disability and Rehabilitation·J F KeatingM Delargy
Oct 1, 1981·The Journal of Clinical Investigation·P MinaireG Pilonchery
Jan 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D ChappardC Picot
Jan 1, 1996·American Journal of Physical Medicine & Rehabilitation·K K BeDellC F Kunkel
Mar 1, 1997·Archives of Physical Medicine and Rehabilitation·E G PearsonS Ludwig
Jan 1, 1997·The Journal of Spinal Cord Medicine·J H Frisbie
Mar 3, 1998·American Journal of Physical Medicine & Rehabilitation·S M SzollarL J Deftos
Feb 20, 1999·Archives of Physical Medicine and Rehabilitation·E D de BruinE Stüssi
Mar 20, 1999·Archives of Physical Medicine and Rehabilitation·P W NanceD Uebelhart
Aug 16, 2000·Archives of Physical Medicine and Rehabilitation·M BélangerB Leduc
Jun 23, 2001·Spinal Cord·M G LazoM Muppidi
Apr 26, 2003·European Journal of Clinical Investigation·P EserE Stüssi
Jan 15, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Yvonne ZehnderKurt Lippuner
Jun 5, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yvonne ZehnderKurt Lippuner
Oct 14, 2004·The Journal of Spinal Cord Medicine·Douglas E GarlandCharles Stewart
Sep 28, 2005·Journal of Rehabilitation Research and Development·William A BaumanErnest Schwartz
Jan 13, 2006·Journal of Neurophysiology·Richard K Shields, Shauna Dudley-Javoroski
Apr 6, 2006·Journal of Rehabilitation Research and Development·William A BaumanErnest Schwartz
Jun 14, 2006·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Lora M GiangregorioNeil McCartney
Jul 11, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Andreas Ludwig ReiterHans Juergen Gerner
Oct 21, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D C L CarvalhoA Cliquet
Jan 18, 2007·The Journal of Clinical Endocrinology and Metabolism·N L GilchristK Marshall
Feb 22, 2007·Neurorehabilitation and Neural Repair·Richard K Shields, Shauna Dudley-Javoroski
Jan 19, 2008·Physical Therapy·Shauna Dudley-Javoroski, Richard K Shields
Jan 30, 2008·Archives of Physical Medicine and Rehabilitation·William C LoganHelen M Hoenig
Jun 27, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L R MorseE Garshick
Jun 28, 2008·The Journal of Spinal Cord Medicine·Ahmet Salim GoktepeSukru Gunduz
Apr 2, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J S BubbearR W Keen
Nov 26, 2010·Annals of Physical and Rehabilitation Medicine·C CharmetantP Calmels

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Citations

Aug 8, 2020·Topics in Spinal Cord Injury Rehabilitation·Cristina L SadowskyJoseph Zinski
Aug 15, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B LeL D Carbone
Jan 25, 2019·Spinal Cord Series and Cases·Christina KokorelisCristina Sadowsky
Jun 27, 2019·Spinal Cord Series and Cases·Yannis Dionyssiotis
Jan 3, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y WuZ Zhang
May 5, 2020·Current Pharmaceutical Design·Ji XinghuaHuo Jianzhong

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