PMID: 7024090Jun 1, 1981Paper

Evidence concerning insulin activity from the structure of a cross-linked derivative

Hoppe-Seyler's Zeitschrift für physiologische Chemie
J CutfieldC Reynolds

Abstract

The important of crystallographic refinement for confident structural description, even at modest resolution, is demonstrated for N alpha A1,N epsilon B29-L,L-2,7-diaminosuberoyl (A2sb) insulin, a cross-linked insulin of low potency. The spatial arrangement of the cross-link itself can be described, and reliable estimates of the accuracy in atomic positions obtained. Comparison of invariant A2sb and native insulins shows a strong structural similarity, especially for the A chain surface residues and the dimer-forming residues of the B chain which have generally been strongly implicated in the receptor-binding region. Evidence from this analysis directs attention to the A chain, particularly the backbone, as being important in interactions with the membrane-bound receptor.

References

Jan 1, 1977·Annual Review of Biochemistry·K Peters, F M Richards
Jun 1, 1979·Canadian Journal of Biochemistry·E J DodsonC D Reynolds
Jul 25, 1979·Journal of Molecular Biology·J F CutfieldC D Reynolds
Nov 1, 1973·Biochemical and Biophysical Research Communications·R Geiger, R Obermeier
Jun 1, 1973·Hoppe-Seyler's Zeitschrift für physiologische Chemie·D Brandenburg, A Wollmer

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Citations

Nov 1, 1996·Protein Science : a Publication of the Protein Society·E De WolfJ Grötzinger
Mar 1, 1997·Protein Science : a Publication of the Protein Society·G KurapkatA Wollmer
Jan 1, 1994·European Biophysics Journal : EBJ·P KrügerA Wollmer
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G D SmithC D Reynolds
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Q X HuaM A Weiss
Mar 12, 2008·The Journal of Biological Chemistry·Qing-xin HuaMichael A Weiss
Jul 28, 2004·Journal of Molecular Biology·Kun HuangMichael A Weiss
Jul 2, 1984·European Journal of Biochemistry·H RenscheidtD A Mercola
Jan 1, 1983·Biopolymers·E J DodsonC D Reynolds
Apr 17, 2007·Journal of Peptide Science : an Official Publication of the European Peptide Society·Lenka ZákováJirí Jirácek
Apr 1, 1986·International Journal of Peptide and Protein Research·S M CutfieldJ F Cutfield
Mar 1, 1982·Hoppe-Seyler's Zeitschrift für physiologische Chemie·A Schüttler, D Brandenburg
Jun 1, 1981·Hoppe-Seyler's Zeitschrift für physiologische Chemie·C C WangD Brandenburg
Mar 1, 1994·Biological Chemistry Hoppe-Seyler·A G SchepkyW G Forssmann
Oct 23, 2019·Applied Microbiology and Biotechnology·Ruifeng MaoYefu Wang
Feb 1, 1987·Biological Chemistry Hoppe-Seyler·P MuckeD Brandenburg
Jun 20, 2018·The Journal of Physical Chemistry. B·Shampa RaghunathanMarkus Meuwly
Jul 19, 2019·The Journal of Physical Chemistry. B·Jasmine L DesmondMarkus Meuwly

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