Evidence for a causal role by human papillomaviruses in prostate cancer - a systematic review

Infectious Agents and Cancer
James S Lawson, Wendy K Glenn

Abstract

It is hypothesised that high risk for cancer human papillomaviruses (HPVs) have a causal role in prostate cancer. In 26 case control studies, high risk HPVs have been identified in benign and prostate cancers. High risk HPVs were identified in 325 (22.6%) of 1284 prostate cancers and in 113 (8.6%) of 1313 normal or benign prostate controls (p = 0.001). High risk HPVs of the same type have been identified in both normal and benign prostate tissues prior to the development of HPV positive prostate cancer. High risk HPVs can be associated with inflammatory prostatitis leading to benign prostate hyperplasia and later prostate cancer. Normal human prostate epithelial cells can be immortalised by experimental exposure to HPVs. HPVs are probably sexually transmitted. The role of HPVs in prostate cancer is complex and differs from HPVs associated cervical cancer. HPV infections may initiate prostate oncogenesis directly and influence oncogenesis indirectly via APOBEC enzymes. HPVs may collaborate with other pathogens in prostate oncogenesis. Although HPVs are only one of many pathogens that have been identified in prostate cancer, they are the only infectious pathogen which can be prevented by vaccination. A causal role for HPVs in pro...Continue Reading

References

Sep 30, 1992·International Journal of Cancer. Journal International Du Cancer·A RotolaE Cassai
Apr 1, 1991·The Journal of Urology·P J McNicol, J G Dodd
Apr 21, 1995·International Journal of Cancer. Journal International Du Cancer·C Moyret-LalleC Theillet
Feb 1, 1993·The Journal of Urology·J G DoddP J McNicol
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·J S RhimG Jay
Feb 18, 1998·International Journal of Cancer. Journal International Du Cancer·J DillnerA Aromaa
Jan 27, 2000·JAMA : the Journal of the American Medical Association·M HisadaB J van den Berg
Feb 22, 2000·British Journal of Cancer·R B HayesJ F Fraumeni
Apr 5, 2001·Journal of Biomedical Science·J L ChangS L Chen
Dec 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Zoltan KorodiMatti Hakama
Aug 9, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Siobhan SutcliffeElizabeth A Platz
Aug 9, 2008·The American Journal of Pathology·Ewa KrawczykRichard Schlegel
Sep 5, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Wen-Yi HuangCharles S Rabkin
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Sep 2, 2009·Memórias do Instituto Oswaldo Cruz·Rodrigo Vellasco Duarte SilvestreRommel Rodríguez Burbano
Sep 17, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Leslie K DennisGregory C Gray
Feb 10, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Siobhan SutcliffeElizabeth A Platz
Jun 26, 2010·BMC Cancer·Margarita L Martinez-FierroAugusto Rojas-Martinez
Jul 29, 2010·Scandinavian Journal of Infectious Diseases·Arezoo AghakhaniAmitis Ramezani
Jan 18, 2011·Pathology Oncology Research : POR·Alice C-H ChenAnnika Antonsson
Aug 30, 2012·Journal of Medical Virology·Ruth TachezyEva Hamsikova
Jun 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Ehsan GhasemianYousef Yahyapour
Oct 3, 2013·Nature Communications·Ka-Wei TangErik Larsson
Nov 30, 2013·Disease Markers·Mariarosa PascaleGiorgio Stanta
Apr 15, 2014·International Journal of Cancer. Journal International Du Cancer·Jean-Damien CombesGary Clifford
May 27, 2014·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Riccardo BartolettiSandra Mazzoli
Aug 12, 2014·BMC Cancer·Melissa A YowGraham G Giles
Sep 13, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Vasiliki MichopoulouDemetrios A Spandidos

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Jun 1, 2021·Frontiers in Oncology·Liese VandeborneGauthier Bouche

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